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The 6-aminoquinolone WC5 inhibits human cytomegalovirus replication at an early stage by interfering with the transactivating activity of viral immediate-early 2 protein.
Loregian A, Mercorelli B, Muratore G, Sinigalia E, Pagni S, Massari S, Gribaudo G, Gatto B, Palumbo M, Tabarrini O, Cecchetti V, Palù G. Loregian A, et al. Among authors: muratore g. Antimicrob Agents Chemother. 2010 May;54(5):1930-40. doi: 10.1128/AAC.01730-09. Epub 2010 Mar 1. Antimicrob Agents Chemother. 2010. PMID: 20194695 Free PMC article.
The 6-Aminoquinolone WC5 inhibits different functions of the immediate-early 2 (IE2) protein of human cytomegalovirus that are essential for viral replication.
Mercorelli B, Luganini A, Muratore G, Massari S, Terlizzi ME, Tabarrini O, Gribaudo G, Palù G, Loregian A. Mercorelli B, et al. Among authors: muratore g. Antimicrob Agents Chemother. 2014 Nov;58(11):6615-26. doi: 10.1128/AAC.03309-14. Epub 2014 Aug 25. Antimicrob Agents Chemother. 2014. PMID: 25155603 Free PMC article.
A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein-Basic Protein 1 (PA-PB1) Subunits.
Massari S, Nannetti G, Desantis J, Muratore G, Sabatini S, Manfroni G, Mercorelli B, Cecchetti V, Palù G, Cruciani G, Loregian A, Goracci L, Tabarrini O. Massari S, et al. Among authors: muratore g. J Med Chem. 2015 May 14;58(9):3830-42. doi: 10.1021/acs.jmedchem.5b00012. Epub 2015 Apr 20. J Med Chem. 2015. PMID: 25856229 Free article.
48 results