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Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.
Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, Habib AA, Stahelin RV, Perrotti D, Ogretmen B. Saddoughi SA, et al. Among authors: ogretmen b. EMBO Mol Med. 2013 Jan;5(1):105-21. doi: 10.1002/emmm.201201283. Epub 2012 Nov 25. EMBO Mol Med. 2013. PMID: 23180565 Free PMC article.
Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.
Ogretmen B, Pettus BJ, Rossi MJ, Wood R, Usta J, Szulc Z, Bielawska A, Obeid LM, Hannun YA. Ogretmen B, et al. J Biol Chem. 2002 Apr 12;277(15):12960-9. doi: 10.1074/jbc.M110699200. Epub 2002 Jan 28. J Biol Chem. 2002. PMID: 11815611 Free article.
Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo.
Senkal CE, Ponnusamy S, Rossi MJ, Sundararaj K, Szulc Z, Bielawski J, Bielawska A, Meyer M, Cobanoglu B, Koybasi S, Sinha D, Day TA, Obeid LM, Hannun YA, Ogretmen B. Senkal CE, et al. Among authors: ogretmen b. J Pharmacol Exp Ther. 2006 Jun;317(3):1188-99. doi: 10.1124/jpet.106.101949. Epub 2006 Mar 1. J Pharmacol Exp Ther. 2006. PMID: 16510697
146 results