Mabery EM - Search Results

1

Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase.

Fenaux M, Eng S, Leavitt SA, Lee YJ, Mabery EM, Tian Y, Byun D, Canales E, Clarke MO, Doerffler E, Lazerwith SE, Lew W, Liu Q, Mertzman M, Morganelli P, Xu L, Ye H, Zhang J, Matles M, Murray BP, Mwangi J, Zhang J, Hashash A, Krawczyk SH, Bidgood AM, Appleby TC, Watkins WJ. Fenaux M, et al. Among authors: mabery em. Antimicrob Agents Chemother. 2013 Feb;57(2):804-10. doi: 10.1128/AAC.02052-12. Epub 2012 Nov 26. Antimicrob Agents Chemother. 2013. PMID: 23183437 Free PMC article. Clinical Trial.

2

Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase.

Shih IH, Vliegen I, Peng B, Yang H, Hebner C, Paeshuyse J, Pürstinger G, Fenaux M, Tian Y, Mabery E, Qi X, Bahador G, Paulson M, Lehman LS, Bondy S, Tse W, Reiser H, Lee WA, Schmitz U, Neyts J, Zhong W. Shih IH, et al. Antimicrob Agents Chemother. 2011 Sep;55(9):4196-203. doi: 10.1128/AAC.00307-11. Epub 2011 Jul 11. Antimicrob Agents Chemother. 2011. PMID: 21746939 Free PMC article.

3

Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection.

Lazerwith SE, Lew W, Zhang J, Morganelli P, Liu Q, Canales E, Clarke MO, Doerffler E, Byun D, Mertzman M, Ye H, Chong L, Xu L, Appleby T, Chen X, Fenaux M, Hashash A, Leavitt SA, Mabery E, Matles M, Mwangi JW, Tian Y, Lee YJ, Zhang J, Zhu C, Murray BP, Watkins WJ. Lazerwith SE, et al. J Med Chem. 2014 Mar 13;57(5):1893-901. doi: 10.1021/jm401420j. Epub 2013 Nov 6. J Med Chem. 2014. PMID: 24144213

4

Clinical and in vitro resistance to GS-9669, a thumb site II nonnucleoside inhibitor of the hepatitis C virus NS5B polymerase.

Dvory-Sobol H, Voitenleitner C, Mabery E, Skurnac T, Lawitz EJ, McHutchison J, Svarovskaia ES, Delaney W, Miller MD, Mo H. Dvory-Sobol H, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6599-606. doi: 10.1128/AAC.02815-14. Epub 2014 Aug 25. Antimicrob Agents Chemother. 2014. PMID: 25155588 Free PMC article. Clinical Trial.

5

Comparison of HCV NS3 protease and NS5B polymerase inhibitor activity in 1a, 1b and 2a replicons and 2a infectious virus.

Paulson MS, Yang H, Shih IH, Feng JY, Mabery EM, Robinson MF, Zhong W, Delaney WE 4th. Paulson MS, et al. Among authors: mabery em. Antiviral Res. 2009 Aug;83(2):135-42. doi: 10.1016/j.antiviral.2009.04.003. Epub 2009 Apr 14. Antiviral Res. 2009. PMID: 19457562

6

Characterization of a novel antibacterial agent that inhibits bacterial translation.

Böddeker N, Bahador G, Gibbs C, Mabery E, Wolf J, Xu L, Watson J. Böddeker N, et al. RNA. 2002 Sep;8(9):1120-8. doi: 10.1017/s1355838202024020. RNA. 2002. PMID: 12358431 Free PMC article.

7

SAR studies on dihydropyrimidinone antibiotics.

Xu L, Zhang L, Jones R, Bryant C, Boddeker N, Mabery E, Bahador G, Watson J, Clough J, Arimilli M, Gillette W, Colagiovanni D, Wang K, Gibbs C, Kim CU. Xu L, et al. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1670-4. doi: 10.1016/j.bmcl.2011.01.099. Epub 2011 Jan 31. Bioorg Med Chem Lett. 2011. PMID: 21324685

8

Synthesis, cytostatic, and antiviral activity of novel 6-[2-(dialkylamino)ethyl]-, 6-(2-alkoxyethyl)-, 6-[2-(alkylsulfanyl)ethyl]-, and 6-[2-(dialkylamino)vinyl]purine nucleosides.

Kuchar M, Hocek M, Pohl R, Votruba I, Shih IH, Mabery E, Mackman R. Kuchar M, et al. Bioorg Med Chem. 2008 Feb 1;16(3):1400-24. doi: 10.1016/j.bmc.2007.10.063. Epub 2007 Oct 23. Bioorg Med Chem. 2008. PMID: 17997319

9

Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides.

Silhár P, Hocek M, Pohl R, Votruba I, Shih IH, Mabery E, Mackman R. Silhár P, et al. Bioorg Med Chem. 2008 Mar 1;16(5):2329-66. doi: 10.1016/j.bmc.2007.11.067. Epub 2007 Nov 29. Bioorg Med Chem. 2008. PMID: 18078757

10

Cytostatic and antiviral 6-arylpurine ribonucleosides. Part 7: synthesis and evaluation of 6-substituted purine l-ribonucleosides.

Hocek M, Silhár P, Shih IH, Mabery E, Mackman R. Hocek M, et al. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5290-3. doi: 10.1016/j.bmcl.2006.07.092. Epub 2006 Aug 14. Bioorg Med Chem Lett. 2006. PMID: 16905315

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