Spasojevic I - Search Results

1

Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.

Jin G, Reitman ZJ, Duncan CG, Spasojevic I, Gooden DM, Rasheed BA, Yang R, Lopez GY, He Y, McLendon RE, Bigner DD, Yan H. Jin G, et al. Among authors: spasojevic i. Cancer Res. 2013 Jan 15;73(2):496-501. doi: 10.1158/0008-5472.CAN-12-2852. Epub 2012 Nov 30. Cancer Res. 2013. PMID: 23204232 Free PMC article.

2

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.

Reitman ZJ, Jin G, Karoly ED, Spasojevic I, Yang J, Kinzler KW, He Y, Bigner DD, Vogelstein B, Yan H. Reitman ZJ, et al. Among authors: spasojevic i. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3270-5. doi: 10.1073/pnas.1019393108. Epub 2011 Feb 2. Proc Natl Acad Sci U S A. 2011. PMID: 21289278 Free PMC article.

3

2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.

Jin G, Reitman ZJ, Spasojevic I, Batinic-Haberle I, Yang J, Schmidt-Kittler O, Bigner DD, Yan H. Jin G, et al. Among authors: spasojevic i. PLoS One. 2011 Feb 4;6(2):e16812. doi: 10.1371/journal.pone.0016812. PLoS One. 2011. PMID: 21326614 Free PMC article.

4

Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.

Osada T, Chen M, Yang XY, Spasojevic I, Vandeusen JB, Hsu D, Clary BM, Clay TM, Chen W, Morse MA, Lyerly HK. Osada T, et al. Among authors: spasojevic i. Cancer Res. 2011 Jun 15;71(12):4172-82. doi: 10.1158/0008-5472.CAN-10-3978. Epub 2011 Apr 29. Cancer Res. 2011. PMID: 21531761 Free PMC article.

5

Mutant IDH1 is required for IDH1 mutated tumor cell growth.

Jin G, Pirozzi CJ, Chen LH, Lopez GY, Duncan CG, Feng J, Spasojevic I, Bigner DD, He Y, Yan H. Jin G, et al. Among authors: spasojevic i. Oncotarget. 2012 Aug;3(8):774-82. doi: 10.18632/oncotarget.577. Oncotarget. 2012. PMID: 22885298 Free PMC article.

6

Enzyme redesign guided by cancer-derived IDH1 mutations.

Reitman ZJ, Choi BD, Spasojevic I, Bigner DD, Sampson JH, Yan H. Reitman ZJ, et al. Among authors: spasojevic i. Nat Chem Biol. 2012 Nov;8(11):887-9. doi: 10.1038/nchembio.1065. Epub 2012 Sep 23. Nat Chem Biol. 2012. PMID: 23001033 Free PMC article.

7

Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.

Reitman ZJ, Duncan CG, Poteet E, Winters A, Yan LJ, Gooden DM, Spasojevic I, Boros LG, Yang SH, Yan H. Reitman ZJ, et al. Among authors: spasojevic i. J Biol Chem. 2014 Aug 22;289(34):23318-28. doi: 10.1074/jbc.M114.575183. Epub 2014 Jul 1. J Biol Chem. 2014. PMID: 24986863 Free PMC article.

8

Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.

Kanju P, Chen Y, Lee W, Yeo M, Lee SH, Romac J, Shahid R, Fan P, Gooden DM, Simon SA, Spasojevic I, Mook RA, Liddle RA, Guilak F, Liedtke WB. Kanju P, et al. Among authors: spasojevic i. Sci Rep. 2016 Jun 1;6:26894. doi: 10.1038/srep26894. Sci Rep. 2016. PMID: 27247148 Free PMC article.

9

Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.

Pirozzi CJ, Carpenter AB, Waitkus MS, Wang CY, Zhu H, Hansen LJ, Chen LH, Greer PK, Feng J, Wang Y, Bock CB, Fan P, Spasojevic I, McLendon RE, Bigner DD, He Y, Yan H. Pirozzi CJ, et al. Among authors: spasojevic i. Mol Cancer Res. 2017 May;15(5):507-520. doi: 10.1158/1541-7786.MCR-16-0485. Epub 2017 Feb 1. Mol Cancer Res. 2017. PMID: 28148827 Free PMC article.

10

Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1^R132H-Induced Metabolic Liabilities.

Waitkus MS, Pirozzi CJ, Moure CJ, Diplas BH, Hansen LJ, Carpenter AB, Yang R, Wang Z, Ingram BO, Karoly ED, Mohney RP, Spasojevic I, McLendon RE, Friedman HS, He Y, Bigner DD, Yan H. Waitkus MS, et al. Among authors: spasojevic i. Cancer Res. 2018 Jan 1;78(1):36-50. doi: 10.1158/0008-5472.CAN-17-1352. Epub 2017 Nov 2. Cancer Res. 2018. PMID: 29097607 Free PMC article.

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