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Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells.
Nam S, Wen W, Schroeder A, Herrmann A, Yu H, Cheng X, Merz KH, Eisenbrand G, Li H, Yuan YC, Jove R. Nam S, et al. Among authors: merz kh. Mol Oncol. 2013 Jun;7(3):369-78. doi: 10.1016/j.molonc.2012.10.013. Epub 2012 Nov 16. Mol Oncol. 2013. PMID: 23206899 Free PMC article.
Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs.
Cheng X, Kim JY, Ghafoory S, Duvaci T, Rafiee R, Theobald J, Alborzinia H, Holenya P, Fredebohm J, Merz KH, Mehrabi A, Hafezi M, Saffari A, Eisenbrand G, Hoheisel JD, Wölfl S. Cheng X, et al. Among authors: merz kh. Mol Oncol. 2016 Jun;10(6):806-24. doi: 10.1016/j.molonc.2016.01.008. Epub 2016 Feb 4. Mol Oncol. 2016. PMID: 26887594 Free PMC article.
Synthesis and cytotoxicity of novel indirubin-5-carboxamides.
Cheng X, Rasqué P, Vatter S, Merz KH, Eisenbrand G. Cheng X, et al. Among authors: merz kh. Bioorg Med Chem. 2010 Jun 15;18(12):4509-15. doi: 10.1016/j.bmc.2010.04.066. Epub 2010 Apr 28. Bioorg Med Chem. 2010. PMID: 20488718
29 results