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Page 1
NVC-422 inactivates Staphylococcus aureus toxins.
Jekle A, Yoon J, Zuck M, Najafi R, Wang L, Shiau T, Francavilla C, Rani SA, Eitzinger C, Nagl M, Anderson M, Debabov D. Jekle A, et al. Antimicrob Agents Chemother. 2013 Feb;57(2):924-9. doi: 10.1128/AAC.01945-12. Epub 2012 Dec 3. Antimicrob Agents Chemother. 2013. PMID: 23208720 Free PMC article.
Sulfonyl-polyol N,N-dichloroamines with rapid, broad-spectrum antimicrobial activity.
Shiau TP, Low E, Kim B, Turtle ED, Francavilla C, O'Mahony DJ, Friedman L, D'Lima L, Jekle A, Debabov D, Zuck M, Alvarez NJ, Anderson M, Najafi RR, Jain RK. Shiau TP, et al. Among authors: jekle a. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5650-3. doi: 10.1016/j.bmcl.2013.08.027. Epub 2013 Aug 17. Bioorg Med Chem Lett. 2013. PMID: 23999044
N-chlorotaurine and its analogues N,N-dichloro-2,2-dimethyltaurine and N-monochloro-2,2-dimethyltaurine are safe and effective bactericidal agents in ex vivo corneal infection models.
Teuchner B, Eitzinger C, Lutz M, Hager T, Schmid E, Bechrakis NE, Zuck M, Jekle A, Debabov D, Anderson M, Nagl M. Teuchner B, et al. Among authors: jekle a. Acta Ophthalmol. 2012 Dec;90(8):e632-7. doi: 10.1111/j.1755-3768.2012.02501.x. Epub 2012 Sep 12. Acta Ophthalmol. 2012. PMID: 22971221 Free article.
Development of tetravalent, bispecific CCR5 antibodies with antiviral activity against CCR5 monoclonal antibody-resistant HIV-1 strains.
Schanzer J, Jekle A, Nezu J, Lochner A, Croasdale R, Dioszegi M, Zhang J, Hoffmann E, Dormeyer W, Stracke J, Schäfer W, Ji C, Heilek G, Cammack N, Brandt M, Umana P, Brinkmann U. Schanzer J, et al. Among authors: jekle a. Antimicrob Agents Chemother. 2011 May;55(5):2369-78. doi: 10.1128/AAC.00215-10. Epub 2011 Feb 7. Antimicrob Agents Chemother. 2011. PMID: 21300827 Free PMC article.
Evaluation of secondary amide replacements in a series of CCR5 antagonists as a means to increase intrinsic membrane permeability. Part 1: Optimization of gem-disubstituted azacycles.
Lemoine RC, Petersen AC, Setti L, Wanner J, Jekle A, Heilek G, deRosier A, Ji C, Berry P, Rotstein D. Lemoine RC, et al. Among authors: jekle a. Bioorg Med Chem Lett. 2010 Jan 15;20(2):704-8. doi: 10.1016/j.bmcl.2009.11.072. Epub 2009 Dec 7. Bioorg Med Chem Lett. 2010. PMID: 20004099
45 results