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Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052.
Fridell RA, Qiu D, Valera L, Wang C, Rose RE, Gao M. Fridell RA, et al. Among authors: gao m. J Virol. 2011 Jul;85(14):7312-20. doi: 10.1128/JVI.00253-11. Epub 2011 May 18. J Virol. 2011. PMID: 21593143 Free PMC article.
It is highly effective against genotype 1 replicons and also displays robust genotype 1 anti-HCV activity in the clinic (M. Gao et al., Nature 465:96-100, 2010). BMS-790052 inhibits genotype 2a JFH1 replicon cells and cell culture infectious virus with 50% effective …
It is highly effective against genotype 1 replicons and also displays robust genotype 1 anti-HCV activity in the clinic (M. Gao …
Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations.
Fridell RA, Wang C, Sun JH, O'Boyle DR 2nd, Nower P, Valera L, Qiu D, Roberts S, Huang X, Kienzle B, Bifano M, Nettles RE, Gao M. Fridell RA, et al. Among authors: gao m. Hepatology. 2011 Dec;54(6):1924-35. doi: 10.1002/hep.24594. Hepatology. 2011. PMID: 21809362 Clinical Trial.
In vitro activity of BMS-790052 on hepatitis C virus genotype 4 NS5A.
Wang C, Jia L, Huang H, Qiu D, Valera L, Huang X, Sun JH, Nower PT, O'Boyle DR 2nd, Gao M, Fridell RA. Wang C, et al. Among authors: gao m. Antimicrob Agents Chemother. 2012 Mar;56(3):1588-90. doi: 10.1128/AAC.06169-11. Epub 2011 Dec 27. Antimicrob Agents Chemother. 2012. PMID: 22203595 Free PMC article.
In vitro activity of daclatasvir on hepatitis C virus genotype 3 NS5A.
Wang C, Valera L, Jia L, Kirk MJ, Gao M, Fridell RA. Wang C, et al. Among authors: gao m. Antimicrob Agents Chemother. 2013 Jan;57(1):611-3. doi: 10.1128/AAC.01874-12. Epub 2012 Oct 22. Antimicrob Agents Chemother. 2013. PMID: 23089758 Free PMC article.
9,803 results