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63 results

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Page 1
Development of a long acting human growth hormone analog suitable for once a week dosing.
Palanki MS, Bhat A, Bolanos B, Brunel F, Del Rosario J, Dettling D, Horn M, Lappe R, Preston R, Sievers A, Stankovic N, Woodnut G, Chen G. Palanki MS, et al. Among authors: lappe r. Bioorg Med Chem Lett. 2013 Jan 15;23(2):402-6. doi: 10.1016/j.bmcl.2012.11.104. Epub 2012 Dec 5. Bioorg Med Chem Lett. 2013. PMID: 23253442
Evolution of potent and stable placental-growth-factor-1-targeting CovX-bodies from phage display peptide discovery.
Bower KE, Lam SN, Oates BD, Del Rosario JR, Corner E, Osothprarop TF, Kinhikar AG, Hoye JA, Preston RR, Murphy RE, Campbell LA, Huang H, Jimenez J, Cao X, Chen G, Ainekulu ZW, Datt AB, Levin NJ, Doppalapudi VR, Pirie-Shepherd SR, Bradshaw C, Woodnutt G, Lappe RW. Bower KE, et al. Among authors: lappe rw. J Med Chem. 2011 Mar 10;54(5):1256-65. doi: 10.1021/jm101226k. Epub 2011 Jan 31. J Med Chem. 2011. PMID: 21280651
Chemical generation of bispecific antibodies.
Doppalapudi VR, Huang J, Liu D, Jin P, Liu B, Li L, Desharnais J, Hagen C, Levin NJ, Shields MJ, Parish M, Murphy RE, Del Rosario J, Oates BD, Lai JY, Matin MJ, Ainekulu Z, Bhat A, Bradshaw CW, Woodnutt G, Lerner RA, Lappe RW. Doppalapudi VR, et al. Among authors: lappe rw. Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22611-6. doi: 10.1073/pnas.1016478108. Epub 2010 Dec 13. Proc Natl Acad Sci U S A. 2010. PMID: 21149738 Free PMC article.
Targeting the ANGPT-TIE2 pathway in malignancy.
Huang H, Bhat A, Woodnutt G, Lappe R. Huang H, et al. Among authors: lappe r. Nat Rev Cancer. 2010 Aug;10(8):575-85. doi: 10.1038/nrc2894. Nat Rev Cancer. 2010. PMID: 20651738 Review.
Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody.
Huang J, Ishino T, Chen G, Rolzin P, Osothprarop TF, Retting K, Li L, Jin P, Matin MJ, Huyghe B, Talukdar S, Bradshaw CW, Palanki M, Violand BN, Woodnutt G, Lappe RW, Ogilvie K, Levin N. Huang J, et al. Among authors: lappe rw. J Pharmacol Exp Ther. 2013 Aug;346(2):270-80. doi: 10.1124/jpet.113.204420. Epub 2013 May 29. J Pharmacol Exp Ther. 2013. PMID: 23720456
Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide.
Liu S, Desharnais J, Sahasrabudhe PV, Jin P, Li W, Oates BD, Shanker S, Banker ME, Chrunyk BA, Song X, Feng X, Griffor M, Jimenez J, Chen G, Tumelty D, Bhat A, Bradshaw CW, Woodnutt G, Lappe RW, Thorarensen A, Qiu X, Withka JM, Wood LD. Liu S, et al. Among authors: lappe rw. Sci Rep. 2016 May 17;6:26071. doi: 10.1038/srep26071. Sci Rep. 2016. PMID: 27184415 Free PMC article.
Antitumor efficacy of a thrombospondin 1 mimetic CovX-body.
Li L, Leedom TA, Do J, Huang H, Lai J, Johnson K, Osothprarop TF, Rizzo JD, Doppalapudi VR, Bradshaw CW, Lappe RW, Woodnutt G, Levin NJ, Pirie-Shepherd SR. Li L, et al. Among authors: lappe rw. Transl Oncol. 2011 Aug;4(4):249-57. doi: 10.1593/tlo.11136. Epub 2011 Aug 1. Transl Oncol. 2011. PMID: 21804921 Free PMC article.
63 results