Bosch DE - Search Results

1

Structural determinants of RGS-RhoGEF signaling critical to Entamoeba histolytica pathogenesis.

Bosch DE, Kimple AJ, Manning AJ, Muller RE, Willard FS, Machius M, Rogers SL, Siderovski DP. Bosch DE, et al. Structure. 2013 Jan 8;21(1):65-75. doi: 10.1016/j.str.2012.11.012. Epub 2012 Dec 20. Structure. 2013. PMID: 23260656 Free PMC article.

2

A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics.

Willard FS, Zheng Z, Guo J, Digby GJ, Kimple AJ, Conley JM, Johnston CA, Bosch D, Willard MD, Watts VJ, Lambert NA, Ikeda SR, Du Q, Siderovski DP. Willard FS, et al. J Biol Chem. 2008 Dec 26;283(52):36698-710. doi: 10.1074/jbc.M804936200. Epub 2008 Nov 4. J Biol Chem. 2008. PMID: 18984596 Free PMC article.

3

Structural determinants of affinity enhancement between GoLoco motifs and G-protein alpha subunit mutants.

Bosch DE, Kimple AJ, Sammond DW, Muller RE, Miley MJ, Machius M, Kuhlman B, Willard FS, Siderovski DP. Bosch DE, et al. J Biol Chem. 2011 Feb 4;286(5):3351-8. doi: 10.1074/jbc.M110.190496. Epub 2010 Nov 29. J Biol Chem. 2011. PMID: 21115486 Free PMC article.

4

Computational design of the sequence and structure of a protein-binding peptide.

Sammond DW, Bosch DE, Butterfoss GL, Purbeck C, Machius M, Siderovski DP, Kuhlman B. Sammond DW, et al. Among authors: bosch de. J Am Chem Soc. 2011 Mar 30;133(12):4190-2. doi: 10.1021/ja110296z. Epub 2011 Mar 9. J Am Chem Soc. 2011. PMID: 21388199 Free PMC article.

5

Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions.

Kosloff M, Travis AM, Bosch DE, Siderovski DP, Arshavsky VY. Kosloff M, et al. Among authors: bosch de. Nat Struct Mol Biol. 2011 Jun 19;18(7):846-53. doi: 10.1038/nsmb.2068. Nat Struct Mol Biol. 2011. PMID: 21685921 Free PMC article.

6

Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.

Kimple AJ, Bosch DE, Giguère PM, Siderovski DP. Kimple AJ, et al. Among authors: bosch de. Pharmacol Rev. 2011 Sep;63(3):728-49. doi: 10.1124/pr.110.003038. Epub 2011 Jul 7. Pharmacol Rev. 2011. PMID: 21737532 Free PMC article. Review.

7

Unique structural and nucleotide exchange features of the Rho1 GTPase of Entamoeba histolytica.

Bosch DE, Wittchen ES, Qiu C, Burridge K, Siderovski DP. Bosch DE, et al. J Biol Chem. 2011 Nov 11;286(45):39236-46. doi: 10.1074/jbc.M111.253898. Epub 2011 Sep 19. J Biol Chem. 2011. PMID: 21930699 Free PMC article.

8

Evaluating modulators of "Regulator of G-protein Signaling" (RGS) proteins.

Bosch DE, Zielinski T, Lowery RG, Siderovski DP. Bosch DE, et al. Curr Protoc Pharmacol. 2012 Mar;Chapter 2:Unit2.8. doi: 10.1002/0471141755.ph0208s56. Curr Protoc Pharmacol. 2012. PMID: 22382998 Free PMC article.

9

A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis.

Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP. Bosch DE, et al. PLoS Pathog. 2012 Feb;8(2):e1002553. doi: 10.1371/journal.ppat.1002553. Epub 2012 Feb 23. PLoS Pathog. 2012. PMID: 22383884 Free PMC article.

10

Entamoeba histolytica Rho1 regulates actin polymerization through a divergent, diaphanous-related formin.

Bosch DE, Yang B, Siderovski DP. Bosch DE, et al. Biochemistry. 2012 Nov 6;51(44):8791-801. doi: 10.1021/bi300954g. Epub 2012 Oct 23. Biochemistry. 2012. PMID: 23050667 Free PMC article.

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