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5-(Perylen-3-yl)ethynyl-arabino-uridine (aUY11), an arabino-based rigid amphipathic fusion inhibitor, targets virion envelope lipids to inhibit fusion of influenza virus, hepatitis C virus, and other enveloped viruses.
Colpitts CC, Ustinov AV, Epand RF, Epand RM, Korshun VA, Schang LM. Colpitts CC, et al. Among authors: ustinov av. J Virol. 2013 Apr;87(7):3640-54. doi: 10.1128/JVI.02882-12. Epub 2013 Jan 2. J Virol. 2013. PMID: 23283943 Free PMC article.
Synthesis and evaluation of anti-HSV activity of new 5-alkynyl-2'-deoxyuridines.
Pchelintseva AA, Skorobogatyj MV, Petrunina AL, Andronova VL, Galegov GA, Astakhova IV, Ustinov AV, Malakhov AD, Korshun VA. Pchelintseva AA, et al. Among authors: ustinov av. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):923-6. doi: 10.1081/ncn-200059280. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16248063
Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses.
St Vincent MR, Colpitts CC, Ustinov AV, Muqadas M, Joyce MA, Barsby NL, Epand RF, Epand RM, Khramyshev SA, Valueva OA, Korshun VA, Tyrrell DL, Schang LM. St Vincent MR, et al. Among authors: ustinov av. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17339-44. doi: 10.1073/pnas.1010026107. Epub 2010 Sep 7. Proc Natl Acad Sci U S A. 2010. PMID: 20823220 Free PMC article.
Compounds based on 5-(perylen-3-ylethynyl)uracil scaffold: High activity against tick-borne encephalitis virus and non-specific activity against enterovirus A.
Chistov AA, Orlov AA, Streshnev PP, Slesarchuk NA, Aparin IO, Rathi B, Brylev VA, Kutyakov SV, Mikhura IV, Ustinov AV, Westman G, Palyulin VA, Jain N, Osolodkin DI, Kozlovskaya LI, Korshun VA. Chistov AA, et al. Among authors: ustinov av. Eur J Med Chem. 2019 Jun 1;171:93-103. doi: 10.1016/j.ejmech.2019.03.029. Epub 2019 Mar 16. Eur J Med Chem. 2019. PMID: 30909022
131 results