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Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples.
Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, Ladu MJ. Tai LM, et al. Among authors: bu g. J Biol Chem. 2013 Feb 22;288(8):5914-26. doi: 10.1074/jbc.M112.442103. Epub 2013 Jan 4. J Biol Chem. 2013. PMID: 23293020 Free PMC article.
Lipoproteins in the central nervous system.
Ladu MJ, Reardon C, Van Eldik L, Fagan AM, Bu G, Holtzman D, Getz GS. Ladu MJ, et al. Among authors: bu g. Ann N Y Acad Sci. 2000 Apr;903:167-75. doi: 10.1111/j.1749-6632.2000.tb06365.x. Ann N Y Acad Sci. 2000. PMID: 10818504 Review.
The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice.
Fryer JD, Demattos RB, McCormick LM, O'Dell MA, Spinner ML, Bales KR, Paul SM, Sullivan PM, Parsadanian M, Bu G, Holtzman DM. Fryer JD, et al. Among authors: bu g. J Biol Chem. 2005 Jul 8;280(27):25754-9. doi: 10.1074/jbc.M502143200. Epub 2005 May 11. J Biol Chem. 2005. PMID: 15888448 Free article.
585 results