Thomas M - Search Results

1

Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα).

Thomas M, Burk O, Klumpp B, Kandel BA, Damm G, Weiss TS, Klein K, Schwab M, Zanger UM. Thomas M, et al. Mol Pharmacol. 2013 Mar;83(3):709-18. doi: 10.1124/mol.112.082503. Epub 2013 Jan 7. Mol Pharmacol. 2013. PMID: 23295386

2

Genetics, epigenetics, and regulation of drug-metabolizing cytochrome p450 enzymes.

Zanger UM, Klein K, Thomas M, Rieger JK, Tremmel R, Kandel BA, Klein M, Magdy T. Zanger UM, et al. Among authors: thomas m. Clin Pharmacol Ther. 2014 Mar;95(3):258-61. doi: 10.1038/clpt.2013.220. Epub 2013 Nov 6. Clin Pharmacol Ther. 2014. PMID: 24196843 Review. No abstract available.

3

Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes.

Kandel BA, Thomas M, Winter S, Damm G, Seehofer D, Burk O, Schwab M, Zanger UM. Kandel BA, et al. Among authors: thomas m. Biochim Biophys Acta. 2016 Sep;1859(9):1218-1227. doi: 10.1016/j.bbagrm.2016.03.007. Epub 2016 Mar 17. Biochim Biophys Acta. 2016. PMID: 26994748

4

PPARA: a novel genetic determinant of CYP3A4 in vitro and in vivo.

Klein K, Thomas M, Winter S, Nussler AK, Niemi M, Schwab M, Zanger UM. Klein K, et al. Among authors: thomas m. Clin Pharmacol Ther. 2012 Jun;91(6):1044-52. doi: 10.1038/clpt.2011.336. Clin Pharmacol Ther. 2012. PMID: 22510778

5

Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells.

Thomas M, Bayha C, Vetter S, Hofmann U, Schwarz M, Zanger UM, Braeuning A. Thomas M, et al. Mol Pharmacol. 2015 Jun;87(6):1013-20. doi: 10.1124/mol.114.097402. Epub 2015 Mar 30. Mol Pharmacol. 2015. PMID: 25824487

6

The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes.

Thomas M, Bayha C, Klein K, Müller S, Weiss TS, Schwab M, Zanger UM. Thomas M, et al. BMC Cancer. 2015 Jun 30;15:488. doi: 10.1186/s12885-015-1500-x. BMC Cancer. 2015. PMID: 26122096 Free PMC article.

7

Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8.

Thomas M, Winter S, Klumpp B, Turpeinen M, Klein K, Schwab M, Zanger UM. Thomas M, et al. Front Pharmacol. 2015 Nov 4;6:261. doi: 10.3389/fphar.2015.00261. eCollection 2015. Front Pharmacol. 2015. PMID: 26582990 Free PMC article.

8

The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes.

Johänning J, Kröner P, Thomas M, Zanger UM, Nörenberg A, Eichelbaum M, Schwab M, Brauch H, Schroth W, Mürdter TE. Johänning J, et al. Among authors: thomas m. Arch Toxicol. 2018 Mar;92(3):1099-1112. doi: 10.1007/s00204-017-2147-y. Epub 2017 Dec 28. Arch Toxicol. 2018. PMID: 29285606 Free PMC article.

9

A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells.

Klein M, Thomas M, Hofmann U, Seehofer D, Damm G, Zanger UM. Klein M, et al. Among authors: thomas m. Drug Metab Dispos. 2015 Feb;43(2):273-83. doi: 10.1124/dmd.114.060962. Epub 2014 Dec 5. Drug Metab Dispos. 2015. PMID: 25480923

10

Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists.

Braeuning A, Thomas M, Hofmann U, Vetter S, Zeller E, Petzuch B, Johänning J, Schroth W, Weiss TS, Zanger UM, Schwarz M. Braeuning A, et al. Among authors: thomas m. Drug Metab Dispos. 2015 Nov;43(11):1781-7. doi: 10.1124/dmd.115.064667. Epub 2015 Aug 26. Drug Metab Dispos. 2015. PMID: 26310804

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