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Page 1
iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.
Issuree PD, Maretzky T, McIlwain DR, Monette S, Qing X, Lang PA, Swendeman SL, Park-Min KH, Binder N, Kalliolias GD, Yarilina A, Horiuchi K, Ivashkiv LB, Mak TW, Salmon JE, Blobel CP. Issuree PD, et al. Among authors: lang pa. J Clin Invest. 2013 Feb;123(2):928-32. doi: 10.1172/JCI66168. Epub 2013 Jan 25. J Clin Invest. 2013. PMID: 23348744 Free PMC article.
Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.
Maney SK, McIlwain DR, Polz R, Pandyra AA, Sundaram B, Wolff D, Ohishi K, Maretzky T, Brooke MA, Evers A, Vasudevan AA, Aghaeepour N, Scheller J, Münk C, Häussinger D, Mak TW, Nolan GP, Kelsell DP, Blobel CP, Lang KS, Lang PA. Maney SK, et al. Among authors: lang pa, lang ks. Sci Signal. 2015 Nov 3;8(401):ra109. doi: 10.1126/scisignal.aac5356. Sci Signal. 2015. PMID: 26535007 Free PMC article.
iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.
McIlwain DR, Lang PA, Maretzky T, Hamada K, Ohishi K, Maney SK, Berger T, Murthy A, Duncan G, Xu HC, Lang KS, Häussinger D, Wakeham A, Itie-Youten A, Khokha R, Ohashi PS, Blobel CP, Mak TW. McIlwain DR, et al. Among authors: lang pa, lang ks. Science. 2012 Jan 13;335(6065):229-32. doi: 10.1126/science.1214448. Science. 2012. PMID: 22246778 Free PMC article.
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells.
Brüstle A, Brenner D, Knobbe CB, Lang PA, Virtanen C, Hershenfield BM, Reardon C, Lacher SM, Ruland J, Ohashi PS, Mak TW. Brüstle A, et al. Among authors: lang pa. J Clin Invest. 2012 Dec;122(12):4698-709. doi: 10.1172/JCI63528. Epub 2012 Nov 1. J Clin Invest. 2012. PMID: 23114599 Free PMC article.
iRhom2 inhibits bile duct obstruction-induced liver fibrosis.
Sundaram B, Behnke K, Belancic A, Al-Salihi MA, Thabet Y, Polz R, Pellegrino R, Zhuang Y, Shinde PV, Xu HC, Vasilevska J, Longerich T, Herebian D, Mayatepek E, Bock HH, May P, Kordes C, Aghaeepour N, Mak TW, Keitel V, Häussinger D, Scheller J, Pandyra AA, Lang KS, Lang PA. Sundaram B, et al. Among authors: lang pa, lang ks. Sci Signal. 2019 Oct 29;12(605):eaax1194. doi: 10.1126/scisignal.aax1194. Sci Signal. 2019. PMID: 31662486
Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection.
Xu HC, Huang J, Khairnar V, Duhan V, Pandyra AA, Grusdat M, Shinde P, McIlwain DR, Maney SK, Gommerman J, Löhning M, Ohashi PS, Mak TW, Pieper K, Sic H, Speletas M, Eibel H, Ware CF, Tumanov AV, Kruglov AA, Nedospasov SA, Häussinger D, Recher M, Lang KS, Lang PA. Xu HC, et al. Among authors: lang pa, lang ks. J Virol. 2015 May;89(9):4748-59. doi: 10.1128/JVI.02976-14. Epub 2015 Feb 11. J Virol. 2015. PMID: 25673724 Free PMC article.
RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production.
Maney SK, Xu HC, Huang J, Pandyra AA, Ehlting C, Aguilar-Valenzuela R, Pozdeev VI, McIlwain DR, Zimmermann A, Bode JG, Hengel H, Kirschning CJ, Kim IR, Hiscott J, Brenner D, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA. Maney SK, et al. Among authors: lang pa, lang ks. Cell Physiol Biochem. 2016;39(4):1271-80. doi: 10.1159/000447832. Epub 2016 Sep 8. Cell Physiol Biochem. 2016. PMID: 27606466 Free article.
NK Cells Regulate CD8+ T Cell Mediated Autoimmunity.
Lang PA, Crome SQ, Xu HC, Lang KS, Chapatte L, Deenick EK, Grusdat M, Pandyra AA, Pozdeev VI, Wang R, Holderried TAW, Cantor H, Diefenbach A, Elford AR, McIlwain DR, Recher M, Häussinger D, Mak TW, Ohashi PS. Lang PA, et al. Among authors: lang ks. Front Cell Infect Microbiol. 2020 Feb 13;10:36. doi: 10.3389/fcimb.2020.00036. eCollection 2020. Front Cell Infect Microbiol. 2020. PMID: 32117809 Free PMC article.
220 results