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Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene.
Campbell JL Jr, Clewell HJ 3rd, Van Landingham C, Gentry PR, Andersen ME. Campbell JL Jr, et al. Among authors: clewell hj 3rd. Front Pharmacol. 2023 Aug 17;14:1223808. doi: 10.3389/fphar.2023.1223808. eCollection 2023. Front Pharmacol. 2023. PMID: 37663267 Free PMC article.
Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment - A case study with parabens.
Ouedraogo G, Alexander-White C, Bury D, Clewell HJ 3rd, Cronin M, Cull T, Dent M, Desprez B, Detroyer A, Ellison C, Giammanco S, Hack E, Hewitt NJ, Kenna G, Klaric M, Kreiling R, Lester C, Mahony C, Mombelli E, Naciff J, O'Brien J, Schepky A, Tozer S, van der Burg B, van Vugt-Lussenburg B, Stuard S, Cosmetics Europe. Ouedraogo G, et al. Among authors: clewell hj 3rd. Regul Toxicol Pharmacol. 2022 Jul;132:105161. doi: 10.1016/j.yrtph.2022.105161. Epub 2022 May 1. Regul Toxicol Pharmacol. 2022. PMID: 35508214 Free article.
Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms.
Andersen ME, Hagenbuch B, Apte U, Corton JC, Fletcher T, Lau C, Roth WL, Staels B, Vega GL, Clewell HJ 3rd, Longnecker MP. Andersen ME, et al. Among authors: clewell hj 3rd. Toxicology. 2021 Jul;459:152845. doi: 10.1016/j.tox.2021.152845. Epub 2021 Jul 8. Toxicology. 2021. PMID: 34246716 Free PMC article. Review.
New framework for a non-animal approach adequately assures the safety of cosmetic ingredients - A case study on caffeine.
Bury D, Alexander-White C, Clewell HJ 3rd, Cronin M, Desprez B, Detroyer A, Efremenko A, Firman J, Hack E, Hewitt NJ, Kenna G, Klaric M, Lester C, Mahony C, Ouedraogo G, Paini A, Schepky A; Cosmetics Europe. Bury D, et al. Among authors: clewell hj 3rd. Regul Toxicol Pharmacol. 2021 Jul;123:104931. doi: 10.1016/j.yrtph.2021.104931. Epub 2021 Apr 24. Regul Toxicol Pharmacol. 2021. PMID: 33905778 Free article.
Integration of paraquat pharmacokinetic data across species using PBPK modelling.
Campbell JL Jr, Travis KZ, Clewell HJ 3rd, Stevens AJ, Hinderliter PM, Andersen ME, Botham PA, Cook AR, Minnema DJ, Wolf DC. Campbell JL Jr, et al. Among authors: clewell hj 3rd. Toxicol Appl Pharmacol. 2021 Apr 15;417:115462. doi: 10.1016/j.taap.2021.115462. Epub 2021 Feb 22. Toxicol Appl Pharmacol. 2021. PMID: 33631233 Free article.
Paraquat pharmacokinetics in primates and extrapolation to humans.
Stevens AJ, Campbell JL Jr, Travis KZ, Clewell HJ 3rd, Hinderliter PM, Botham PA, Cook AR, Minnema DJ, Wolf DC. Stevens AJ, et al. Among authors: clewell hj 3rd. Toxicol Appl Pharmacol. 2021 Apr 15;417:115463. doi: 10.1016/j.taap.2021.115463. Epub 2021 Feb 22. Toxicol Appl Pharmacol. 2021. PMID: 33631232 Free article.
Response to "letter concerning: Clewell (2019) incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene." (UIHT-2020-0053).
Clewell HJ 3rd, Campbell JL, Van Landingham C, Franzen A, Yoon M, Dodd DE, Andersen ME, Gentry PR. Clewell HJ 3rd, et al. Inhal Toxicol. 2020 Aug;32(9-10):369-371. doi: 10.1080/08958378.2020.1817199. Epub 2020 Sep 8. Inhal Toxicol. 2020. PMID: 32900235 No abstract available.
155 results