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The heparanase/syndecan-1 axis in cancer: mechanisms and therapies.
Ramani VC, Purushothaman A, Stewart MD, Thompson CA, Vlodavsky I, Au JL, Sanderson RD. Ramani VC, et al. FEBS J. 2013 May;280(10):2294-306. doi: 10.1111/febs.12168. Epub 2013 Mar 4. FEBS J. 2013. PMID: 23374281 Free PMC article. Review.
SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis.
Ritchie JP, Ramani VC, Ren Y, Naggi A, Torri G, Casu B, Penco S, Pisano C, Carminati P, Tortoreto M, Zunino F, Vlodavsky I, Sanderson RD, Yang Y. Ritchie JP, et al. Among authors: ramani vc. Clin Cancer Res. 2011 Mar 15;17(6):1382-93. doi: 10.1158/1078-0432.CCR-10-2476. Epub 2011 Jan 21. Clin Cancer Res. 2011. PMID: 21257720 Free PMC article.
Chemotherapy induces secretion of exosomes loaded with heparanase that degrades extracellular matrix and impacts tumor and host cell behavior.
Bandari SK, Purushothaman A, Ramani VC, Brinkley GJ, Chandrashekar DS, Varambally S, Mobley JA, Zhang Y, Brown EE, Vlodavsky I, Sanderson RD. Bandari SK, et al. Among authors: ramani vc. Matrix Biol. 2018 Jan;65:104-118. doi: 10.1016/j.matbio.2017.09.001. Epub 2017 Sep 6. Matrix Biol. 2018. PMID: 28888912 Free PMC article.
Heparanase promotes myeloma stemness and in vivo tumorigenesis.
Tripathi K, Ramani VC, Bandari SK, Amin R, Brown EE, Ritchie JP, Stewart MD, Sanderson RD. Tripathi K, et al. Among authors: ramani vc. Matrix Biol. 2020 Jun;88:53-68. doi: 10.1016/j.matbio.2019.11.004. Epub 2019 Dec 5. Matrix Biol. 2020. PMID: 31812535 Free PMC article.
28 results