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The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability.
Predmore BL, Kondo K, Bhushan S, Zlatopolsky MA, King AL, Aragon JP, Grinsfelder DB, Condit ME, Lefer DJ. Predmore BL, et al. Among authors: kondo k. Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2410-8. doi: 10.1152/ajpheart.00044.2012. Epub 2012 Mar 30. Am J Physiol Heart Circ Physiol. 2012. PMID: 22467307 Free PMC article.
Selective β2-adrenoreceptor stimulation attenuates myocardial cell death and preserves cardiac function after ischemia-reperfusion injury.
Bhushan S, Kondo K, Predmore BL, Zlatopolsky M, King AL, Pearce C, Huang H, Tao YX, Condit ME, Lefer DJ. Bhushan S, et al. Among authors: kondo k. Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1865-74. doi: 10.1161/ATVBAHA.112.251769. Epub 2012 May 31. Arterioscler Thromb Vasc Biol. 2012. PMID: 22652602 Free PMC article.
Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent.
King AL, Polhemus DJ, Bhushan S, Otsuka H, Kondo K, Nicholson CK, Bradley JM, Islam KN, Calvert JW, Tao YX, Dugas TR, Kelley EE, Elrod JW, Huang PL, Wang R, Lefer DJ. King AL, et al. Among authors: kondo k. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3182-7. doi: 10.1073/pnas.1321871111. Epub 2014 Feb 10. Proc Natl Acad Sci U S A. 2014. PMID: 24516168 Free PMC article.
The NHLBI-sponsored Consortium for preclinicAl assESsment of cARdioprotective therapies (CAESAR): a new paradigm for rigorous, accurate, and reproducible evaluation of putative infarct-sparing interventions in mice, rabbits, and pigs.
Jones SP, Tang XL, Guo Y, Steenbergen C, Lefer DJ, Kukreja RC, Kong M, Li Q, Bhushan S, Zhu X, Du J, Nong Y, Stowers HL, Kondo K, Hunt GN, Goodchild TT, Orr A, Chang CC, Ockaili R, Salloum FN, Bolli R. Jones SP, et al. Among authors: kondo k. Circ Res. 2015 Feb 13;116(4):572-86. doi: 10.1161/CIRCRESAHA.116.305462. Epub 2014 Dec 11. Circ Res. 2015. PMID: 25499773 Free PMC article.
4,358 results