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RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis.
Reynolds A, Qiao H, Yang Y, Chen JK, Jackson N, Biswas K, Holloway JK, Baudat F, de Massy B, Wang J, Höög C, Cohen PE, Hunter N. Reynolds A, et al. Among authors: yang y. Nat Genet. 2013 Mar;45(3):269-78. doi: 10.1038/ng.2541. Epub 2013 Feb 10. Nat Genet. 2013. PMID: 23396135 Free PMC article.
PCNA activates the MutLγ endonuclease to promote meiotic crossing over.
Kulkarni DS, Owens SN, Honda M, Ito M, Yang Y, Corrigan MW, Chen L, Quan AL, Hunter N. Kulkarni DS, et al. Among authors: yang y. Nature. 2020 Oct;586(7830):623-627. doi: 10.1038/s41586-020-2645-6. Epub 2020 Aug 19. Nature. 2020. PMID: 32814343 Free PMC article.
SUMO fosters assembly and functionality of the MutSγ complex to facilitate meiotic crossing over.
He W, Verhees GF, Bhagwat N, Yang Y, Kulkarni DS, Lombardo Z, Lahiri S, Roy P, Zhuo J, Dang B, Snyder A, Shastry S, Moezpoor M, Alocozy L, Lee KG, Painter D, Mukerji I, Hunter N. He W, et al. Among authors: yang y. Dev Cell. 2021 Jul 26;56(14):2073-2088.e3. doi: 10.1016/j.devcel.2021.06.012. Epub 2021 Jul 1. Dev Cell. 2021. PMID: 34214491 Free PMC article.
Targeted animal models for preclinical assessment of cellular and gene therapies in pancreatic and liver diseases: regulatory and practical insights.
Wang H, Ciccocioppo R, Terai S, Shoeibi S, Carnevale G, De Marchi G, Tsuchiya A, Ishii S, Tonouchi T, Furuyama K, Yang Y, Mito M, Abe H, Di Tinco R, Cardinale V. Wang H, et al. Among authors: yang y. Cytotherapy. 2024 Nov 19:S1465-3249(24)00934-4. doi: 10.1016/j.jcyt.2024.11.008. Online ahead of print. Cytotherapy. 2024. PMID: 39755978
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