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Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury.
Arslan F, Lai RC, Smeets MB, Akeroyd L, Choo A, Aguor EN, Timmers L, van Rijen HV, Doevendans PA, Pasterkamp G, Lim SK, de Kleijn DP. Arslan F, et al. Among authors: lai rc. Stem Cell Res. 2013 May;10(3):301-12. doi: 10.1016/j.scr.2013.01.002. Epub 2013 Jan 14. Stem Cell Res. 2013. PMID: 23399448 Free article.
Derivation and characterization of human fetal MSCs: an alternative cell source for large-scale production of cardioprotective microparticles.
Lai RC, Arslan F, Tan SS, Tan B, Choo A, Lee MM, Chen TS, Teh BJ, Eng JK, Sidik H, Tanavde V, Hwang WS, Lee CN, El Oakley RM, Pasterkamp G, de Kleijn DP, Tan KH, Lim SK. Lai RC, et al. J Mol Cell Cardiol. 2010 Jun;48(6):1215-24. doi: 10.1016/j.yjmcc.2009.12.021. Epub 2010 Jan 11. J Mol Cell Cardiol. 2010. PMID: 20064522
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury.
Lai RC, Arslan F, Lee MM, Sze NS, Choo A, Chen TS, Salto-Tellez M, Timmers L, Lee CN, El Oakley RM, Pasterkamp G, de Kleijn DP, Lim SK. Lai RC, et al. Stem Cell Res. 2010 May;4(3):214-22. doi: 10.1016/j.scr.2009.12.003. Epub 2010 Jan 4. Stem Cell Res. 2010. PMID: 20138817 Free article.
86 results