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Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury.
Arslan F, Lai RC, Smeets MB, Akeroyd L, Choo A, Aguor EN, Timmers L, van Rijen HV, Doevendans PA, Pasterkamp G, Lim SK, de Kleijn DP. Arslan F, et al. Among authors: timmers l. Stem Cell Res. 2013 May;10(3):301-12. doi: 10.1016/j.scr.2013.01.002. Epub 2013 Jan 14. Stem Cell Res. 2013. PMID: 23399448 Free article.
Cyclooxygenase-2 inhibition increases mortality, enhances left ventricular remodeling, and impairs systolic function after myocardial infarction in the pig.
Timmers L, Sluijter JP, Verlaan CW, Steendijk P, Cramer MJ, Emons M, Strijder C, Gründeman PF, Sze SK, Hua L, Piek JJ, Borst C, Pasterkamp G, de Kleijn DP. Timmers L, et al. Circulation. 2007 Jan 23;115(3):326-32. doi: 10.1161/CIRCULATIONAHA.106.647230. Epub 2007 Jan 8. Circulation. 2007. PMID: 17210840
Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody.
Arslan F, Smeets MB, O'Neill LA, Keogh B, McGuirk P, Timmers L, Tersteeg C, Hoefer IE, Doevendans PA, Pasterkamp G, de Kleijn DP. Arslan F, et al. Among authors: timmers l. Circulation. 2010 Jan 5;121(1):80-90. doi: 10.1161/CIRCULATIONAHA.109.880187. Epub 2009 Dec 21. Circulation. 2010. PMID: 20026776
215 results