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Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.
Puntel M, A K M GM, Farrokhi C, Vanderveen N, Paran C, Appelhans A, Kroeger KM, Salem A, Lacayo L, Pechnick RN, Kelson KR, Kaur S, Kennedy S, Palmer D, Ng P, Liu C, Krasinkiewicz J, Lowenstein PR, Castro MG. Puntel M, et al. Among authors: liu c. Toxicol Appl Pharmacol. 2013 May 1;268(3):318-30. doi: 10.1016/j.taap.2013.02.001. Epub 2013 Feb 9. Toxicol Appl Pharmacol. 2013. PMID: 23403069 Free PMC article.
Study of the efficacy, biodistribution, and safety profile of therapeutic gutless adenovirus vectors as a prelude to a phase I clinical trial for glioblastoma.
Muhammad AK, Puntel M, Candolfi M, Salem A, Yagiz K, Farrokhi C, Kroeger KM, Xiong W, Curtin JF, Liu C, Lawrence K, Bondale NS, Lerner J, Baker GJ, Foulad D, Pechnick RN, Palmer D, Ng P, Lowenstein PR, Castro MG. Muhammad AK, et al. Among authors: liu c. Clin Pharmacol Ther. 2010 Aug;88(2):204-13. doi: 10.1038/clpt.2009.260. Epub 2010 Feb 17. Clin Pharmacol Ther. 2010. PMID: 20164833 Free PMC article.
Efficacy of nonviral gene transfer in the canine brain.
Oh S, Pluhar GE, McNeil EA, Kroeger KM, Liu C, Castro MG, Lowenstein PR, Freese A, Ohlfest JR. Oh S, et al. Among authors: liu c. J Neurosurg. 2007 Jul;107(1):136-44. doi: 10.3171/JNS-07/07/0136. J Neurosurg. 2007. PMID: 17639883 Free PMC article.
A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics.
Puntel M, Muhammad AK, Candolfi M, Salem A, Yagiz K, Farrokhi C, Kroeger KM, Xiong W, Curtin JF, Liu C, Bondale NS, Lerner J, Pechnick RN, Palmer D, Ng P, Lowenstein PR, Castro MG. Puntel M, et al. Among authors: liu c. J Virol. 2010 Jun;84(12):6007-17. doi: 10.1128/JVI.00398-10. Epub 2010 Apr 7. J Virol. 2010. PMID: 20375153 Free PMC article.
Targeted toxins for glioblastoma multiforme: pre-clinical studies and clinical implementation.
Candolfi M, Kroeger KM, Xiong W, Liu C, Puntel M, Yagiz K, Muhammad AG, Mineharu Y, Foulad D, Wibowo M, Assi H, Baker GJ, Lowenstein PR, Castro MG. Candolfi M, et al. Among authors: liu c. Anticancer Agents Med Chem. 2011 Oct;11(8):729-38. doi: 10.2174/187152011797378689. Anticancer Agents Med Chem. 2011. PMID: 21707497 Free PMC article. Review.
Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial.
Muhammad AK, Xiong W, Puntel M, Farrokhi C, Kroeger KM, Salem A, Lacayo L, Pechnick RN, Kelson KR, Palmer D, Ng P, Liu C, Lowenstein PR, Castro MG. Muhammad AK, et al. Among authors: liu c. Hum Gene Ther Methods. 2012 Aug;23(4):271-84. doi: 10.1089/hgtb.2012.060. Epub 2012 Sep 5. Hum Gene Ther Methods. 2012. PMID: 22950971 Free PMC article.
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