Williams O - Search Results

1

The AAA+ ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesis.

Osaki H, Walf-Vorderwülbecke V, Mangolini M, Zhao L, Horton SJ, Morrone G, Schuringa JJ, de Boer J, Williams O. Osaki H, et al. Among authors: williams o. Leukemia. 2013 Jul;27(7):1461-8. doi: 10.1038/leu.2013.42. Epub 2013 Feb 13. Leukemia. 2013. PMID: 23403462

2

TEL-AML1 promotes development of specific hematopoietic lineages consistent with preleukemic activity.

Morrow M, Horton S, Kioussis D, Brady HJ, Williams O. Morrow M, et al. Among authors: williams o. Blood. 2004 May 15;103(10):3890-6. doi: 10.1182/blood-2003-10-3695. Epub 2004 Jan 15. Blood. 2004. PMID: 14726384 Free article.

3

Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells.

Horton SJ, Grier DG, McGonigle GJ, Thompson A, Morrow M, De Silva I, Moulding DA, Kioussis D, Lappin TR, Brady HJ, Williams O. Horton SJ, et al. Among authors: williams o. Cancer Res. 2005 Oct 15;65(20):9245-52. doi: 10.1158/0008-5472.CAN-05-1691. Cancer Res. 2005. PMID: 16230385

4

The mechanism of hematopoietic progenitor cell immortalization by MLL-ENL.

Horton SJ, Williams O. Horton SJ, et al. Among authors: williams o. Cell Cycle. 2006 Feb;5(4):360-2. doi: 10.4161/cc.5.4.2464. Epub 2006 Feb 15. Cell Cycle. 2006. PMID: 16479159

5

Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal.

McMahon KA, Hiew SY, Hadjur S, Veiga-Fernandes H, Menzel U, Price AJ, Kioussis D, Williams O, Brady HJ. McMahon KA, et al. Among authors: williams o. Cell Stem Cell. 2007 Sep 13;1(3):338-45. doi: 10.1016/j.stem.2007.07.002. Cell Stem Cell. 2007. PMID: 18371367 Free article.

6

Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities.

Horton SJ, Walf-Vorderwülbecke V, Chatters SJ, Sebire NJ, de Boer J, Williams O. Horton SJ, et al. Among authors: williams o. Blood. 2009 May 14;113(20):4922-9. doi: 10.1182/blood-2008-07-170480. Epub 2008 Nov 24. Blood. 2009. PMID: 19029444 Free article.

7

ERG is a megakaryocytic oncogene.

Salek-Ardakani S, Smooha G, de Boer J, Sebire NJ, Morrow M, Rainis L, Lee S, Williams O, Izraeli S, Brady HJ. Salek-Ardakani S, et al. Among authors: williams o. Cancer Res. 2009 Jun 1;69(11):4665-73. doi: 10.1158/0008-5472.CAN-09-0075. Cancer Res. 2009. PMID: 19487285

8

The RAC specific guanine nucleotide exchange factor Asef functions downstream from TEL-AML1 to promote leukaemic transformation.

Lyons R, Williams O, Morrow M, Sebire N, Hubank M, Anderson J. Lyons R, et al. Among authors: williams o. Leuk Res. 2010 Jan;34(1):109-15. doi: 10.1016/j.leukres.2009.06.032. Epub 2009 Jul 22. Leuk Res. 2010. PMID: 19628279

9

Tnfaip8 is an essential gene for the regulation of glucocorticoid-mediated apoptosis of thymocytes.

Woodward MJ, de Boer J, Heidorn S, Hubank M, Kioussis D, Williams O, Brady HJ. Woodward MJ, et al. Among authors: williams o. Cell Death Differ. 2010 Feb;17(2):316-23. doi: 10.1038/cdd.2009.125. Epub 2009 Sep 4. Cell Death Differ. 2010. PMID: 19730441

10

The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development.

Gascoyne DM, Long E, Veiga-Fernandes H, de Boer J, Williams O, Seddon B, Coles M, Kioussis D, Brady HJ. Gascoyne DM, et al. Among authors: williams o. Nat Immunol. 2009 Oct;10(10):1118-24. doi: 10.1038/ni.1787. Epub 2009 Sep 13. Nat Immunol. 2009. PMID: 19749763

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