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Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.
Martin ES, Belmont PJ, Sinnamon MJ, Richard LG, Yuan J, Coffee EM, Roper J, Lee L, Heidari P, Lunt SY, Goel G, Ji X, Xie Z, Xie T, Lamb J, Weinrich SL, VanArsdale T, Bronson RT, Xavier RJ, Vander Heiden MG, Kan JL, Mahmood U, Hung KE. Martin ES, et al. Among authors: xavier rj. Clin Cancer Res. 2013 Jun 1;19(11):2929-40. doi: 10.1158/1078-0432.CCR-12-2307. Epub 2013 Feb 12. Clin Cancer Res. 2013. PMID: 23403635 Free PMC article.
Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.
Coffee EM, Faber AC, Roper J, Sinnamon MJ, Goel G, Keung L, Wang WV, Vecchione L, de Vriendt V, Weinstein BJ, Bronson RT, Tejpar S, Xavier RJ, Engelman JA, Martin ES, Hung KE. Coffee EM, et al. Among authors: xavier rj. Clin Cancer Res. 2013 May 15;19(10):2688-98. doi: 10.1158/1078-0432.CCR-12-2556. Epub 2013 Apr 2. Clin Cancer Res. 2013. PMID: 23549875 Free PMC article.
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang JK, Israelsen WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Xavier RJ, O'Neill LA. Palsson-McDermott EM, et al. Among authors: xavier rj. Cell Metab. 2015 Jan 6;21(1):65-80. doi: 10.1016/j.cmet.2014.12.005. Cell Metab. 2015. PMID: 25565206 Free PMC article.
Discovery of a Small-Molecule Probe for V-ATPase Function.
Aldrich LN, Kuo SY, Castoreno AB, Goel G, Kuballa P, Rees MG, Seashore-Ludlow BA, Cheah JH, Latorre IJ, Schreiber SL, Shamji AF, Xavier RJ. Aldrich LN, et al. Among authors: xavier rj. J Am Chem Soc. 2015 Apr 29;137(16):5563-8. doi: 10.1021/jacs.5b02150. Epub 2015 Apr 20. J Am Chem Soc. 2015. PMID: 25860544 Free PMC article.
Mechanisms of Pediatric Inflammatory Bowel Disease.
Peloquin JM, Goel G, Villablanca EJ, Xavier RJ. Peloquin JM, et al. Among authors: xavier rj. Annu Rev Immunol. 2016 May 20;34:31-64. doi: 10.1146/annurev-immunol-032414-112151. Annu Rev Immunol. 2016. PMID: 27168239 Review.
HIF-1alpha and HIF-2alpha have divergent roles in colon cancer.
Imamura T, Kikuchi H, Herraiz MT, Park DY, Mizukami Y, Mino-Kenduson M, Lynch MP, Rueda BR, Benita Y, Xavier RJ, Chung DC. Imamura T, et al. Among authors: xavier rj. Int J Cancer. 2009 Feb 15;124(4):763-71. doi: 10.1002/ijc.24032. Int J Cancer. 2009. PMID: 19030186 Free PMC article.
631 results