Zhao H - Search Results

1

pRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location.

Lu Z, Marcelin G, Bauzon F, Wang H, Fu H, Dun SL, Zhao H, Li X, Jo YH, Wardlaw S, Dun N, Chua S Jr, Zhu L. Lu Z, et al. Among authors: zhao h. EMBO J. 2013 Mar 20;32(6):844-57. doi: 10.1038/emboj.2013.25. Epub 2013 Feb 12. EMBO J. 2013. PMID: 23403926 Free PMC article.

2

Skp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors.

Zhao H, Bauzon F, Fu H, Lu Z, Cui J, Nakayama K, Nakayama KI, Locker J, Zhu L. Zhao H, et al. Cancer Cell. 2013 Nov 11;24(5):645-59. doi: 10.1016/j.ccr.2013.09.021. Cancer Cell. 2013. PMID: 24229711 Free PMC article.

3

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity.

Lu Z, Bauzon F, Fu H, Cui J, Zhao H, Nakayama K, Nakayama KI, Zhu L. Lu Z, et al. Among authors: zhao h. Nat Commun. 2014 Mar 17;5:3463. doi: 10.1038/ncomms4463. Nat Commun. 2014. PMID: 24632684 Free PMC article.

4

Antitumor mechanisms when pRb and p53 are genetically inactivated.

Zhu L, Lu Z, Zhao H. Zhu L, et al. Among authors: zhao h. Oncogene. 2015 Aug 27;34(35):4547-57. doi: 10.1038/onc.2014.399. Epub 2014 Dec 8. Oncogene. 2015. PMID: 25486431 Free PMC article. Review.

5

Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of Rb1 and enhances humoral immunity in old age.

Zhao H, Bauzon F, Bi E, Yu JJ, Fu H, Lu Z, Cui J, Jeon H, Zang X, Ye BH, Zhu L. Zhao H, et al. J Biol Chem. 2015 Feb 27;290(9):5797-809. doi: 10.1074/jbc.M114.625350. Epub 2015 Jan 12. J Biol Chem. 2015. PMID: 25583987 Free PMC article.

6

Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis.

Zhao H, Wang H, Bauzon F, Lu Z, Fu H, Cui J, Zhu L. Zhao H, et al. J Biol Chem. 2016 May 6;291(19):10201-9. doi: 10.1074/jbc.M116.718049. Epub 2016 Mar 10. J Biol Chem. 2016. PMID: 26966181 Free PMC article.

7

p27T187A knockin identifies Skp2/Cks1 pocket inhibitors for advanced prostate cancer.

Zhao H, Lu Z, Bauzon F, Fu H, Cui J, Locker J, Zhu L. Zhao H, et al. Oncogene. 2017 Jan 5;36(1):60-70. doi: 10.1038/onc.2016.175. Epub 2016 May 16. Oncogene. 2017. PMID: 27181203 Free PMC article.

8

Targeted Inhibition of the E3 Ligase SCF^Skp2/Cks1 Has Antitumor Activity in RB1-Deficient Human and Mouse Small-Cell Lung Cancer.

Zhao H, Iqbal NJ, Sukrithan V, Nicholas C, Xue Y, Yu C, Locker J, Zou J, Schwartz EL, Zhu L. Zhao H, et al. Cancer Res. 2020 Jun 1;80(11):2355-2367. doi: 10.1158/0008-5472.CAN-19-2400. Epub 2020 Apr 7. Cancer Res. 2020. PMID: 32265224 Free PMC article.

9

Cyclin-dependent kinase 4/6 inhibitors require an arcuate-to-paraventricular hypothalamus melanocortin circuit to treat diet-induced obesity.

Iqbal NJ, Schwartz GJ, Zhao H, Zhu L, Chua S , Jr. Iqbal NJ, et al. Among authors: zhao h. Am J Physiol Endocrinol Metab. 2021 Mar 1;320(3):E467-E474. doi: 10.1152/ajpendo.00386.2020. Epub 2020 Dec 28. Am J Physiol Endocrinol Metab. 2021. PMID: 33356996 Free PMC article.

10

Effect of HLA Matching on Pediatric Renal Transplant Graft Survival in China.

Zhao H, Lai X, Lu J, Lin Y, Wang P, Zhu L, Wu L, Xiao Z, Wang Q, Tan J. Zhao H, et al. Transplant Proc. 2017 Jul-Aug;49(6):1291-1293. doi: 10.1016/j.transproceed.2017.02.048. Transplant Proc. 2017. PMID: 28735996

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