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Reduced elimination of IgG antibodies by engineering the variable region.
Igawa T, Tsunoda H, Tachibana T, Maeda A, Mimoto F, Moriyama C, Nanami M, Sekimori Y, Nabuchi Y, Aso Y, Hattori K. Igawa T, et al. Among authors: mimoto f. Protein Eng Des Sel. 2010 May;23(5):385-92. doi: 10.1093/protein/gzq009. Epub 2010 Feb 15. Protein Eng Des Sel. 2010. PMID: 20159773
Engineered monoclonal antibody with novel antigen-sweeping activity in vivo.
Igawa T, Maeda A, Haraya K, Tachibana T, Iwayanagi Y, Mimoto F, Higuchi Y, Ishii S, Tamba S, Hironiwa N, Nagano K, Wakabayashi T, Tsunoda H, Hattori K. Igawa T, et al. Among authors: mimoto f. PLoS One. 2013 May 7;8(5):e63236. doi: 10.1371/journal.pone.0063236. Print 2013. PLoS One. 2013. PMID: 23667591 Free PMC article.
Inhibitory FcγRIIb-Mediated Soluble Antigen Clearance from Plasma by a pH-Dependent Antigen-Binding Antibody and Its Enhancement by Fc Engineering.
Iwayanagi Y, Igawa T, Maeda A, Haraya K, Wada NA, Shibahara N, Ohmine K, Nambu T, Nakamura G, Mimoto F, Katada H, Ito S, Tachibana T, Jishage K, Hattori K. Iwayanagi Y, et al. Among authors: mimoto f. J Immunol. 2015 Oct 1;195(7):3198-205. doi: 10.4049/jimmunol.1401470. Epub 2015 Aug 28. J Immunol. 2015. PMID: 26320252 Free PMC article.
Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases.
Fukuzawa T, Sampei Z, Haraya K, Ruike Y, Shida-Kawazoe M, Shimizu Y, Gan SW, Irie M, Tsuboi Y, Tai H, Sakiyama T, Sakamoto A, Ishii S, Maeda A, Iwayanagi Y, Shibahara N, Shibuya M, Nakamura G, Nambu T, Hayasaka A, Mimoto F, Okura Y, Hori Y, Habu K, Wada M, Miura T, Tachibana T, Honda K, Tsunoda H, Kitazawa T, Kawabe Y, Igawa T, Hattori K, Nezu J. Fukuzawa T, et al. Among authors: mimoto f. Sci Rep. 2017 Apr 24;7(1):1080. doi: 10.1038/s41598-017-01087-7. Sci Rep. 2017. PMID: 28439081 Free PMC article.
15 results