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NVP-QBE170: an inhaled blocker of the epithelial sodium channel with a reduced potential to induce hyperkalaemia.
Coote KJ, Paisley D, Czarnecki S, Tweed M, Watson H, Young A, Sugar R, Vyas M, Smith NJ, Baettig U, Groot-Kormelink PJ, Gosling M, Lock R, Ethell B, Williams G, Schumacher A, Harris J, Abraham WM, Sabater J, Poll CT, Faller T, Collingwood SP, Danahay H. Coote KJ, et al. Among authors: lock r. Br J Pharmacol. 2015 Jun;172(11):2814-26. doi: 10.1111/bph.13075. Epub 2015 Apr 23. Br J Pharmacol. 2015. PMID: 25573195 Free PMC article.
Optimizing drugs for local delivery.
Collingwood S, Lock R, Searcey M. Collingwood S, et al. Among authors: lock r. Drug News Perspect. 2009 Dec;22(10):627-34. doi: 10.1358/dnp.2009.10.1437289. Drug News Perspect. 2009. PMID: 20140283 Free article.
Challenges in inhaled product development and opportunities for open innovation.
Forbes B, Asgharian B, Dailey LA, Ferguson D, Gerde P, Gumbleton M, Gustavsson L, Hardy C, Hassall D, Jones R, Lock R, Maas J, McGovern T, Pitcairn GR, Somers G, Wolff RK. Forbes B, et al. Among authors: lock r. Adv Drug Deliv Rev. 2011 Jan-Feb;63(1-2):69-87. doi: 10.1016/j.addr.2010.11.004. Epub 2010 Dec 6. Adv Drug Deliv Rev. 2011. PMID: 21144875 Review.
Targeting LMO2-induced autocrine FLT3 signaling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia.
Tremblay CS, Saw J, Yan F, Boyle JA, Amarasinghe O, Abdollahi S, Vo ANQ, Shields BJ, Mayoh C, McCalmont H, Evans K, Steiner A, Parsons K, McCormack MP, Powell DR, Wong NC, Jane SM, Lock RB, Curtis DJ. Tremblay CS, et al. Among authors: lock rb. Leukemia. 2025 Jan 23. doi: 10.1038/s41375-024-02491-5. Online ahead of print. Leukemia. 2025. PMID: 39849166
The CD123 antibody-drug conjugate pivekimab sunirine exerts profound activity in preclinical models of pediatric acute lymphoblastic leukemia.
Watts B, Smith CM, Evans K, Gifford AJ, Mohamed SMA, Erickson SW, Earley EJ, Neuhauser S, Stearns TM, Philip VM, Chuang JH, Zweidler-McKay PA, Lakshmikanthan S, Jocoy EL, Bult CJ, Teicher BA, Smith MA, Lock RB. Watts B, et al. Among authors: lock rb. Hemasphere. 2025 Jan 17;9(1):e70063. doi: 10.1002/hem3.70063. eCollection 2025 Jan. Hemasphere. 2025. PMID: 39830370 Free PMC article.
Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy.
Wang BZ, Morsink MA, Kim SW, Luo LJ, Zhang X, Soni RK, Lock RI, Rao J, Kim Y, Zhang A, Neyazi M, Gorham JM, Kim Y, Brown K, DeLaughter DM, Zhang Q, McDonough B, Watkins JM, Cunningham KM, Oudit GY, Fine BM, Seidman CE, Seidman JG, Vunjak-Novakovic G. Wang BZ, et al. Among authors: lock ri. J Clin Invest. 2025 Jan 2;135(1):e181630. doi: 10.1172/JCI181630. J Clin Invest. 2025. PMID: 39744939 Free PMC article.
439 results