Ma C - Search Results

1

Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus.

Wang J, Ma C, Wang J, Jo H, Canturk B, Fiorin G, Pinto LH, Lamb RA, Klein ML, DeGrado WF. Wang J, et al. Among authors: ma c. J Med Chem. 2013 Apr 11;56(7):2804-12. doi: 10.1021/jm301538e. Epub 2013 Mar 27. J Med Chem. 2013. PMID: 23437766 Free PMC article.

2

Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus.

Ma C, Soto CS, Ohigashi Y, Taylor A, Bournas V, Glawe B, Udo MK, Degrado WF, Lamb RA, Pinto LH. Ma C, et al. J Biol Chem. 2008 Jun 6;283(23):15921-31. doi: 10.1074/jbc.M710302200. Epub 2008 Apr 11. J Biol Chem. 2008. PMID: 18408016 Free PMC article.

3

The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus.

Stouffer AL, Ma C, Cristian L, Ohigashi Y, Lamb RA, Lear JD, Pinto LH, DeGrado WF. Stouffer AL, et al. Among authors: ma c. Structure. 2008 Jul;16(7):1067-76. doi: 10.1016/j.str.2008.04.011. Structure. 2008. PMID: 18611380 Free PMC article.

4

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel.

Jing X, Ma C, Ohigashi Y, Oliveira FA, Jardetzky TS, Pinto LH, Lamb RA. Jing X, et al. Among authors: ma c. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10967-72. doi: 10.1073/pnas.0804958105. Epub 2008 Jul 31. Proc Natl Acad Sci U S A. 2008. PMID: 18669647 Free PMC article.

5

pH-induced conformational change of the influenza M2 protein C-terminal domain.

Nguyen PA, Soto CS, Polishchuk A, Caputo GA, Tatko CD, Ma C, Ohigashi Y, Pinto LH, DeGrado WF, Howard KP. Nguyen PA, et al. Among authors: ma c. Biochemistry. 2008 Sep 23;47(38):9934-6. doi: 10.1021/bi801315m. Epub 2008 Aug 29. Biochemistry. 2008. PMID: 18754675 Free PMC article.

6

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel.

Ma C, Polishchuk AL, Ohigashi Y, Stouffer AL, Schön A, Magavern E, Jing X, Lear JD, Freire E, Lamb RA, DeGrado WF, Pinto LH. Ma C, et al. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12283-8. doi: 10.1073/pnas.0905726106. Epub 2009 Jul 9. Proc Natl Acad Sci U S A. 2009. PMID: 19590009 Free PMC article.

7

An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition.

Ohigashi Y, Ma C, Jing X, Balannick V, Pinto LH, Lamb RA. Ohigashi Y, et al. Among authors: ma c. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18775-9. doi: 10.1073/pnas.0910584106. Epub 2009 Oct 19. Proc Natl Acad Sci U S A. 2009. PMID: 19841275 Free PMC article.

8

A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein.

Polishchuk AL, Lear JD, Ma C, Lamb RA, Pinto LH, Degrado WF. Polishchuk AL, et al. Among authors: ma c. Biochemistry. 2010 Nov 30;49(47):10061-71. doi: 10.1021/bi101229m. Epub 2010 Nov 3. Biochemistry. 2010. PMID: 20968306 Free PMC article.

9

Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus.

Duque MD, Ma C, Torres E, Wang J, Naesens L, Juárez-Jiménez J, Camps P, Luque FJ, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. Duque MD, et al. Among authors: ma c. J Med Chem. 2011 Apr 28;54(8):2646-57. doi: 10.1021/jm101334y. Epub 2011 Apr 5. J Med Chem. 2011. PMID: 21466220 Free PMC article.

10

Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus.

Wang J, Ma C, Balannik V, Pinto LH, Lamb RA, Degrado WF. Wang J, et al. Among authors: ma c. ACS Med Chem Lett. 2011 Apr 14;2(4):307-312. doi: 10.1021/ml100297w. ACS Med Chem Lett. 2011. PMID: 21691418 Free PMC article.

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