Almo SC - Search Results

1

Catalytic site conformations in human PNP by 19F-NMR and crystallography.

Suarez J, Haapalainen AM, Cahill SM, Ho MC, Yan F, Almo SC, Schramm VL. Suarez J, et al. Among authors: almo sc. Chem Biol. 2013 Feb 21;20(2):212-22. doi: 10.1016/j.chembiol.2013.01.009. Chem Biol. 2013. PMID: 23438750 Free PMC article.

2

Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function.

Shi W, Ting LM, Kicska GA, Lewandowicz A, Tyler PC, Evans GB, Furneaux RH, Kim K, Almo SC, Schramm VL. Shi W, et al. Among authors: almo sc. J Biol Chem. 2004 Apr 30;279(18):18103-6. doi: 10.1074/jbc.C400068200. Epub 2004 Feb 23. J Biol Chem. 2004. PMID: 14982926 Free article.

3

Acyclic immucillin phosphonates: second-generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.

Hazleton KZ, Ho MC, Cassera MB, Clinch K, Crump DR, Rosario I Jr, Merino EF, Almo SC, Tyler PC, Schramm VL. Hazleton KZ, et al. Among authors: almo sc. Chem Biol. 2012 Jun 22;19(6):721-30. doi: 10.1016/j.chembiol.2012.04.012. Chem Biol. 2012. PMID: 22726686 Free PMC article.

4

A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT.

Burgos ES, Ho MC, Almo SC, Schramm VL. Burgos ES, et al. Among authors: almo sc. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13748-53. doi: 10.1073/pnas.0903898106. Epub 2009 Aug 4. Proc Natl Acad Sci U S A. 2009. PMID: 19666527 Free PMC article.

5

Four generations of transition-state analogues for human purine nucleoside phosphorylase.

Ho MC, Shi W, Rinaldo-Matthis A, Tyler PC, Evans GB, Clinch K, Almo SC, Schramm VL. Ho MC, et al. Among authors: almo sc. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4805-12. doi: 10.1073/pnas.0913439107. Epub 2010 Mar 8. Proc Natl Acad Sci U S A. 2010. PMID: 20212140 Free PMC article.

6

Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase.

Guan R, Ho MC, Brenowitz M, Tyler PC, Evans GB, Almo SC, Schramm VL. Guan R, et al. Among authors: almo sc. Biochemistry. 2011 Nov 29;50(47):10408-17. doi: 10.1021/bi201321x. Epub 2011 Nov 7. Biochemistry. 2011. PMID: 21985704 Free PMC article.

7

Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration.

Shi W, Sarver AE, Wang CC, Tanaka KS, Almo SC, Schramm VL. Shi W, et al. Among authors: almo sc. J Biol Chem. 2002 Oct 18;277(42):39981-8. doi: 10.1074/jbc.M205596200. Epub 2002 Aug 8. J Biol Chem. 2002. PMID: 12171925 Free article.

8

Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase.

Kicska GA, Tyler PC, Evans GB, Furneaux RH, Shi W, Fedorov A, Lewandowicz A, Cahill SM, Almo SC, Schramm VL. Kicska GA, et al. Among authors: almo sc. Biochemistry. 2002 Dec 10;41(49):14489-98. doi: 10.1021/bi026636f. Biochemistry. 2002. PMID: 12463747

9

Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase.

Lewandowicz A, Shi W, Evans GB, Tyler PC, Furneaux RH, Basso LA, Santos DS, Almo SC, Schramm VL. Lewandowicz A, et al. Among authors: almo sc. Biochemistry. 2003 May 27;42(20):6057-66. doi: 10.1021/bi0343830. Biochemistry. 2003. PMID: 12755607

10

Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A.

Singh V, Shi W, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL. Singh V, et al. Among authors: almo sc. Biochemistry. 2004 Jan 13;43(1):9-18. doi: 10.1021/bi0358420. Biochemistry. 2004. PMID: 14705926

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