Liu Q - Search Results

1

Free energy landscape for the binding process of Huperzine A to acetylcholinesterase.

Bai F, Xu Y, Chen J, Liu Q, Gu J, Wang X, Ma J, Li H, Onuchic JN, Jiang H. Bai F, et al. Among authors: liu q. Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4273-8. doi: 10.1073/pnas.1301814110. Epub 2013 Feb 25. Proc Natl Acad Sci U S A. 2013. PMID: 23440190 Free PMC article.

2

Novel fatty acid binding protein 4 (FABP4) inhibitors: virtual screening, synthesis and crystal structure determination.

Cai H, Liu Q, Gao D, Wang T, Chen T, Yan G, Chen K, Xu Y, Wang H, Li Y, Zhu W. Cai H, et al. Among authors: liu q. Eur J Med Chem. 2015 Jan 27;90:241-50. doi: 10.1016/j.ejmech.2014.11.020. Epub 2014 Nov 11. Eur J Med Chem. 2015. PMID: 25461324

3

Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors.

Liu Q, Chen X, Chen W, Yuan X, Su H, Shen J, Xu Y. Liu Q, et al. J Med Chem. 2016 May 26;59(10):5115-20. doi: 10.1021/acs.jmedchem.6b00282. Epub 2016 Apr 26. J Med Chem. 2016. PMID: 27078579

4

Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors.

Yuan H, Liu Q, Zhang L, Hu S, Chen T, Li H, Chen Y, Xu Y, Lu T. Yuan H, et al. Among authors: liu q. Eur J Med Chem. 2018 Jan 1;143:491-502. doi: 10.1016/j.ejmech.2017.11.073. Epub 2017 Dec 2. Eur J Med Chem. 2018. PMID: 29202410

5

Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.

Wang Y, Dai Y, Wu X, Li F, Liu B, Li C, Liu Q, Zhou Y, Wang B, Zhu M, Cui R, Tan X, Xiong Z, Liu J, Tan M, Xu Y, Geng M, Jiang H, Liu H, Ai J, Zheng M. Wang Y, et al. Among authors: liu j, liu h, liu b, liu q. J Med Chem. 2019 Aug 22;62(16):7473-7488. doi: 10.1021/acs.jmedchem.9b00510. Epub 2019 Aug 9. J Med Chem. 2019. PMID: 31335138

6

Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.

Zhou Y, Fu Y, Yin W, Li J, Wang W, Bai F, Xu S, Gong Q, Peng T, Hong Y, Zhang D, Zhang D, Liu Q, Xu Y, Xu HE, Zhang H, Jiang H, Liu H. Zhou Y, et al. Among authors: liu h, liu q. J Med Chem. 2021 Feb 25;64(4):1844-1855. doi: 10.1021/acs.jmedchem.0c01863. Epub 2021 Feb 11. J Med Chem. 2021. PMID: 33570950

7

Insights into divalent cation regulation and G₁₃-coupling of orphan receptor GPR35.

Duan J, Liu Q, Yuan Q, Ji Y, Zhu S, Tan Y, He X, Xu Y, Shi J, Cheng X, Jiang H, Eric Xu H, Jiang Y. Duan J, et al. Among authors: liu q. Cell Discov. 2022 Dec 21;8(1):135. doi: 10.1038/s41421-022-00499-8. Cell Discov. 2022. PMID: 36543774 Free PMC article.

8

Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors.

Ye N, Chen CH, Chen T, Song Z, He JX, Huan XJ, Song SS, Liu Q, Chen Y, Ding J, Xu Y, Miao ZH, Zhang A. Ye N, et al. Among authors: liu q. J Med Chem. 2013 Apr 11;56(7):2885-903. doi: 10.1021/jm301825t. Epub 2013 Mar 21. J Med Chem. 2013. PMID: 23473053

9

Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity.

Zhan Z, Ai J, Liu Q, Ji Y, Chen T, Xu Y, Geng M, Duan W. Zhan Z, et al. Among authors: liu q. ACS Med Chem Lett. 2014 Mar 26;5(6):673-8. doi: 10.1021/ml500066m. eCollection 2014 Jun 12. ACS Med Chem Lett. 2014. PMID: 24944742 Free PMC article.

10

Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor.

Zhan Z, Peng X, Liu Q, Chen F, Ji Y, Yao S, Xi Y, Lin Y, Chen T, Xu Y, Ai J, Geng M, Duan W. Zhan Z, et al. Among authors: liu q. Eur J Med Chem. 2016 Jun 30;116:239-251. doi: 10.1016/j.ejmech.2016.03.076. Epub 2016 Mar 31. Eur J Med Chem. 2016. PMID: 27061987

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