Keeton AB - Search Results

1

A novel sulindac derivative inhibits lung adenocarcinoma cell growth through suppression of Akt/mTOR signaling and induction of autophagy.

Gurpinar E, Grizzle WE, Shacka JJ, Mader BJ, Li N, Piazza NA, Russo S, Keeton AB, Piazza GA. Gurpinar E, et al. Among authors: keeton ab. Mol Cancer Ther. 2013 May;12(5):663-74. doi: 10.1158/1535-7163.MCT-12-0785. Epub 2013 Feb 26. Mol Cancer Ther. 2013. PMID: 23443799 Free PMC article.

2

Suppression of Wnt/beta-catenin signaling inhibits prostate cancer cell proliferation.

Lu W, Tinsley HN, Keeton A, Qu Z, Piazza GA, Li Y. Lu W, et al. Eur J Pharmacol. 2009 Jan 5;602(1):8-14. doi: 10.1016/j.ejphar.2008.10.053. Epub 2008 Nov 9. Eur J Pharmacol. 2009. PMID: 19026633 Free PMC article.

3

A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity.

Piazza GA, Keeton AB, Tinsley HN, Gary BD, Whitt JD, Mathew B, Thaiparambil J, Coward L, Gorman G, Li Y, Sani B, Hobrath JV, Maxuitenko YY, Reynolds RC. Piazza GA, et al. Among authors: keeton ab. Cancer Prev Res (Phila). 2009 Jun;2(6):572-80. doi: 10.1158/1940-6207.CAPR-09-0001. Epub 2009 May 26. Cancer Prev Res (Phila). 2009. PMID: 19470791 Free PMC article.

4

Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents.

Abadi AH, Abouel-Ella DA, Ahmed NS, Gary BD, Thaiparambil JT, Tinsley HN, Keeton AB, Piazza GA. Abadi AH, et al. Among authors: keeton ab. Arzneimittelforschung. 2009;59(8):415-21. doi: 10.1055/s-0031-1296417. Arzneimittelforschung. 2009. PMID: 19813465 Free PMC article.

5

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G.

Tinsley HN, Gary BD, Keeton AB, Zhang W, Abadi AH, Reynolds RC, Piazza GA. Tinsley HN, et al. Among authors: keeton ab. Mol Cancer Ther. 2009 Dec;8(12):3331-40. doi: 10.1158/1535-7163.MCT-09-0758. Mol Cancer Ther. 2009. PMID: 19996273 Free PMC article.

6

Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.

Tinsley HN, Gary BD, Thaiparambil J, Li N, Lu W, Li Y, Maxuitenko YY, Keeton AB, Piazza GA. Tinsley HN, et al. Among authors: keeton ab. Cancer Prev Res (Phila). 2010 Oct;3(10):1303-13. doi: 10.1158/1940-6207.CAPR-10-0030. Epub 2010 Sep 28. Cancer Prev Res (Phila). 2010. PMID: 20876730 Free PMC article.

7

A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cells.

Li HF, Keeton A, Vitolo M, Maddox C, Rasmussen L, Hobrath J, White EL, Park BH, Piazza GA, Kim JS, Waldman T. Li HF, et al. J Biomol Screen. 2011 Apr;16(4):383-93. doi: 10.1177/1087057110397357. Epub 2011 Feb 18. J Biomol Screen. 2011. PMID: 21335596 Free PMC article.

8

Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells.

Tinsley HN, Gary BD, Keeton AB, Lu W, Li Y, Piazza GA. Tinsley HN, et al. Among authors: keeton ab. Cancer Prev Res (Phila). 2011 Aug;4(8):1275-84. doi: 10.1158/1940-6207.CAPR-11-0095. Epub 2011 Apr 19. Cancer Prev Res (Phila). 2011. PMID: 21505183 Free PMC article.

9

A novel sulindac derivative that potently suppresses colon tumor cell growth by inhibiting cGMP phosphodiesterase and β-catenin transcriptional activity.

Whitt JD, Li N, Tinsley HN, Chen X, Zhang W, Li Y, Gary BD, Keeton AB, Xi Y, Abadi AH, Grizzle WE, Piazza GA. Whitt JD, et al. Among authors: keeton ab. Cancer Prev Res (Phila). 2012 Jun;5(6):822-33. doi: 10.1158/1940-6207.CAPR-11-0559. Epub 2012 May 3. Cancer Prev Res (Phila). 2012. PMID: 22556201 Free PMC article.

10

New NSAID targets and derivatives for colorectal cancer chemoprevention.

Tinsley HN, Grizzle WE, Abadi A, Keeton A, Zhu B, Xi Y, Piazza GA. Tinsley HN, et al. Recent Results Cancer Res. 2013;191:105-20. doi: 10.1007/978-3-642-30331-9_6. Recent Results Cancer Res. 2013. PMID: 22893202 Free PMC article. Review.

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