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Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.
Keough DT, Špaček P, Hocková D, Tichý T, Vrbková S, Slavětínská L, Janeba Z, Naesens L, Edstein MD, Chavchich M, Wang TH, de Jersey J, Guddat LW. Keough DT, et al. Among authors: slavetinska l. J Med Chem. 2013 Mar 28;56(6):2513-26. doi: 10.1021/jm301893b. Epub 2013 Mar 19. J Med Chem. 2013. PMID: 23448281
C1'-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase.
Kalčic F, Frydrych J, Doleželová E, Slapničková M, Pachl P, Slavětínská LP, Dračínský M, Hocková D, Zíková A, Janeba Z. Kalčic F, et al. Among authors: slavetinska lp. Eur J Med Chem. 2021 Dec 5;225:113798. doi: 10.1016/j.ejmech.2021.113798. Epub 2021 Aug 25. Eur J Med Chem. 2021. PMID: 34482272
Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with α-ketoamide warheads.
Šimková A, Ormsby T, Sidej N, Slavětínská LP, Brynda J, Beranová J, Šácha P, Majer P, Konvalinka J. Šimková A, et al. Among authors: slavetinska lp. Eur J Med Chem. 2021 Nov 15;224:113717. doi: 10.1016/j.ejmech.2021.113717. Epub 2021 Jul 31. Eur J Med Chem. 2021. PMID: 34371463 Free article.
Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2'-C-methylribonucleosides, 2'-deoxy-2'-fluoroarabinonucleosides, arabinonucleosides and 2'-deoxyribonucleosides.
Nauš P, Perlíková P, Bourderioux A, Pohl R, Slavětínská L, Votruba I, Bahador G, Birkuš G, Cihlář T, Hocek M. Nauš P, et al. Among authors: slavetinska l. Bioorg Med Chem. 2012 Sep 1;20(17):5202-14. doi: 10.1016/j.bmc.2012.07.003. Epub 2012 Jul 20. Bioorg Med Chem. 2012. PMID: 22877872
Synthesis and Antitrypanosomal Activity of 6-Substituted 7-Methyl-7-deazapurine Nucleosides.
Perlíková P, Krajczyk A, Doleželová E, Slapničková M, Milisavljevic N, Slavětínská LP, Tloušt'ová E, Gurská S, Džubák P, Hajdúch M, Zíková A, Hocek M. Perlíková P, et al. Among authors: slavetinska lp. ACS Infect Dis. 2021 Apr 9;7(4):917-926. doi: 10.1021/acsinfecdis.1c00062. Epub 2021 Mar 26. ACS Infect Dis. 2021. PMID: 33769794
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