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Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides.
Fong LG, Vickers TA, Farber EA, Choi C, Yun UJ, Hu Y, Yang SH, Coffinier C, Lee R, Yin L, Davies BS, Andres DA, Spielmann HP, Bennett CF, Young SG. Fong LG, et al. Among authors: hu y. Hum Mol Genet. 2009 Jul 1;18(13):2462-71. doi: 10.1093/hmg/ddp184. Epub 2009 Apr 17. Hum Mol Genet. 2009. PMID: 19376814 Free PMC article.
Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium.
Smith S, Witkowski A, Moghul A, Yoshinaga Y, Nefedov M, de Jong P, Feng D, Fong L, Tu Y, Hu Y, Young SG, Pham T, Cheung C, Katzman SM, Brand MD, Quinlan CL, Fens M, Kuypers F, Misquitta S, Griffey SM, Tran S, Gharib A, Knudsen J, Hannibal-Bach HK, Wang G, Larkin S, Thweatt J, Pasta S. Smith S, et al. Among authors: hu y. PLoS One. 2012;7(10):e47196. doi: 10.1371/journal.pone.0047196. Epub 2012 Oct 15. PLoS One. 2012. PMID: 23077570 Free PMC article.
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