Young SG - Search Results

1

Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs.

Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P. Villanueva CJ, et al. Among authors: young sg. Cell Metab. 2013 Mar 5;17(3):423-35. doi: 10.1016/j.cmet.2013.01.016. Cell Metab. 2013. PMID: 23473036 Free PMC article.

2

Lamin B1 is required for mouse development and nuclear integrity.

Vergnes L, Péterfy M, Bergo MO, Young SG, Reue K. Vergnes L, et al. Among authors: young sg. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10428-33. doi: 10.1073/pnas.0401424101. Epub 2004 Jul 1. Proc Natl Acad Sci U S A. 2004. PMID: 15232008 Free PMC article.

3

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice.

Fong LG, Ng JK, Meta M, Coté N, Yang SH, Stewart CL, Sullivan T, Burghardt A, Majumdar S, Reue K, Bergo MO, Young SG. Fong LG, et al. Among authors: young sg. Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18111-6. doi: 10.1073/pnas.0408558102. Epub 2004 Dec 17. Proc Natl Acad Sci U S A. 2004. PMID: 15608054 Free PMC article.

4

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

Yang SH, Bergo MO, Toth JI, Qiao X, Hu Y, Sandoval S, Meta M, Bendale P, Gelb MH, Young SG, Fong LG. Yang SH, et al. Among authors: young sg. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10291-6. doi: 10.1073/pnas.0504641102. Epub 2005 Jul 12. Proc Natl Acad Sci U S A. 2005. PMID: 16014412 Free PMC article.

5

Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes.

Toth JI, Yang SH, Qiao X, Beigneux AP, Gelb MH, Moulson CL, Miner JH, Young SG, Fong LG. Toth JI, et al. Among authors: young sg. Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12873-8. doi: 10.1073/pnas.0505767102. Epub 2005 Aug 29. Proc Natl Acad Sci U S A. 2005. PMID: 16129834 Free PMC article.

6

Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis.

Young SG, Fong LG, Michaelis S. Young SG, et al. J Lipid Res. 2005 Dec;46(12):2531-58. doi: 10.1194/jlr.R500011-JLR200. Epub 2005 Oct 5. J Lipid Res. 2005. PMID: 16207929 Free article. Review.

7

Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity.

Vergnes L, Beigneux AP, Davis R, Watkins SM, Young SG, Reue K. Vergnes L, et al. Among authors: young sg. J Lipid Res. 2006 Apr;47(4):745-54. doi: 10.1194/jlr.M500553-JLR200. Epub 2006 Jan 25. J Lipid Res. 2006. PMID: 16436371 Free PMC article.

8

Agpat6--a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium.

Beigneux AP, Vergnes L, Qiao X, Quatela S, Davis R, Watkins SM, Coleman RA, Walzem RL, Philips M, Reue K, Young SG. Beigneux AP, et al. Among authors: young sg. J Lipid Res. 2006 Apr;47(4):734-44. doi: 10.1194/jlr.M500556-JLR200. Epub 2006 Jan 31. J Lipid Res. 2006. PMID: 16449762 Free PMC article.

9

A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

Fong LG, Frost D, Meta M, Qiao X, Yang SH, Coffinier C, Young SG. Fong LG, et al. Among authors: young sg. Science. 2006 Mar 17;311(5767):1621-3. doi: 10.1126/science.1124875. Epub 2006 Feb 16. Science. 2006. PMID: 16484451

10

Prelamin A and lamin A appear to be dispensable in the nuclear lamina.

Fong LG, Ng JK, Lammerding J, Vickers TA, Meta M, Coté N, Gavino B, Qiao X, Chang SY, Young SR, Yang SH, Stewart CL, Lee RT, Bennett CF, Bergo MO, Young SG. Fong LG, et al. Among authors: young sr, young sg. J Clin Invest. 2006 Mar;116(3):743-52. doi: 10.1172/JCI27125. J Clin Invest. 2006. PMID: 16511604 Free PMC article.

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