Johnston WA - Search Results

1

DNA shuffling of cytochrome P450 enzymes.

Behrendorff JB, Johnston WA, Gillam EM. Behrendorff JB, et al. Among authors: johnston wa. Methods Mol Biol. 2013;987:177-88. doi: 10.1007/978-1-62703-321-3_16. Methods Mol Biol. 2013. PMID: 23475678

2

Extending the diversity of cytochrome P450 enzymes by DNA family shuffling.

Rosic NN, Huang W, Johnston WA, DeVoss JJ, Gillam EM. Rosic NN, et al. Among authors: johnston wa. Gene. 2007 Jun 15;395(1-2):40-8. doi: 10.1016/j.gene.2007.01.031. Epub 2007 Feb 20. Gene. 2007. PMID: 17400405

3

A shuffled CYP1A library shows both structural integrity and functional diversity.

Johnston WA, Huang W, De Voss JJ, Hayes MA, Gillam EM. Johnston WA, et al. Drug Metab Dispos. 2007 Dec;35(12):2177-85. doi: 10.1124/dmd.107.017939. Epub 2007 Sep 6. Drug Metab Dispos. 2007. PMID: 17823232

4

A shuffled CYP2C library with a high degree of structural integrity and functional versatility.

Huang W, Johnston WA, Hayes MA, De Voss JJ, Gillam EM. Huang W, et al. Among authors: johnston wa. Arch Biochem Biophys. 2007 Nov 15;467(2):193-205. doi: 10.1016/j.abb.2007.08.023. Epub 2007 Aug 30. Arch Biochem Biophys. 2007. PMID: 17904094

5

Quantitative whole-cell cytochrome P450 measurement suitable for high-throughput application.

Johnston WA, Huang W, De Voss JJ, Hayes MA, Gillam EM. Johnston WA, et al. J Biomol Screen. 2008 Feb;13(2):135-41. doi: 10.1177/1087057107312780. Epub 2008 Jan 23. J Biomol Screen. 2008. PMID: 18216397

6

Facile production of minor metabolites for drug development using a CYP3A shuffled library.

Hunter DJ, Behrendorff JB, Johnston WA, Hayes PY, Huang W, Bonn B, Hayes MA, De Voss JJ, Gillam EM. Hunter DJ, et al. Among authors: johnston wa. Metab Eng. 2011 Nov;13(6):682-93. doi: 10.1016/j.ymben.2011.09.001. Epub 2011 Sep 22. Metab Eng. 2011. PMID: 21963485

7

Cytochrome P450 is present in both ferrous and ferric forms in the resting state within intact Escherichia coli and hepatocytes.

Johnston WA, Hunter DJ, Noble CJ, Hanson GR, Stok JE, Hayes MA, De Voss JJ, Gillam EM. Johnston WA, et al. J Biol Chem. 2011 Nov 25;286(47):40750-9. doi: 10.1074/jbc.M111.300871. Epub 2011 Oct 5. J Biol Chem. 2011. PMID: 21976668 Free PMC article.

8

Directed evolution reveals requisite sequence elements in the functional expression of P450 2F1 in Escherichia coli.

Behrendorff JB, Moore CD, Kim KH, Kim DH, Smith CA, Johnston WA, Yun CH, Yost GS, Gillam EM. Behrendorff JB, et al. Among authors: johnston wa. Chem Res Toxicol. 2012 Sep 17;25(9):1964-74. doi: 10.1021/tx300281g. Epub 2012 Aug 29. Chem Res Toxicol. 2012. PMID: 22901340 Free PMC article.

9

Measurement of P450 difference spectra using intact cells.

Johnston WA, Gillam EM. Johnston WA, et al. Methods Mol Biol. 2013;987:189-204. doi: 10.1007/978-1-62703-321-3_17. Methods Mol Biol. 2013. PMID: 23475679

Whole-cell spectral techniques are derived from methods that have been used for a long time to study P450s in microsomal or other subcellular fractions (Omura T and Sato R, J Biol Chem 239:2370-2378, 1964; Schenkman JB et al., Biochemistry 11:4243-4251, 1972), but recent studies …

Whole-cell spectral techniques are derived from methods that have been used for a long time to study P450s in microsomal or other subcellula …

10

Production of eukaryotic cell-free lysate from Leishmania tarentolae.

Johnston WA, Alexandrov K. Johnston WA, et al. Methods Mol Biol. 2014;1118:1-15. doi: 10.1007/978-1-62703-782-2_1. Methods Mol Biol. 2014. PMID: 24395406

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