West M - Search Results

1

Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer.

Bradshaw-Pierce EL, Pitts TM, Tan AC, McPhillips K, West M, Gustafson DL, Halsey C, Nguyen L, Lee NV, Kan JL, Murray BW, Eckhardt SG. Bradshaw-Pierce EL, et al. Among authors: west m. Front Pharmacol. 2013 Mar 22;4:22. doi: 10.3389/fphar.2013.00022. eCollection 2013. Front Pharmacol. 2013. PMID: 23524533 Free PMC article.

2

Organic Anion-Transporting Polypeptide 1B1/1B3-Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro-In Vivo Evaluation in Cynomolgus Monkey.

Eng H, Bi YA, West MA, Ryu S, Yamaguchi E, Kosa RE, Tess DA, Griffith DA, Litchfield J, Kalgutkar AS, Varma MVS. Eng H, et al. J Pharmacol Exp Ther. 2021 Apr;377(1):169-180. doi: 10.1124/jpet.120.000457. Epub 2021 Jan 28. J Pharmacol Exp Ther. 2021. PMID: 33509903

3

Biomarker-Informed Model-Based Risk Assessment of Organic Anion Transporting Polypeptide 1B Mediated Drug-Drug Interactions.

Kimoto E, Costales C, West MA, Bi YA, Vourvahis M, David Rodrigues A, Varma MVS. Kimoto E, et al. Among authors: west ma. Clin Pharmacol Ther. 2022 Feb;111(2):404-415. doi: 10.1002/cpt.2434. Epub 2021 Oct 22. Clin Pharmacol Ther. 2022. PMID: 34605015

4

Translatability of in vitro Inhibition Potency to in vivo P-Glycoprotein Mediated Drug Interaction Risk.

Lazzaro S, West MA, Eatemadpour S, Feng B, Varma MVS, Rodrigues AD, Temesszentandrási-Ambrus C, Kovács-Hajdu P, Nerada Z, Gáborik Z, Costales C. Lazzaro S, et al. J Pharm Sci. 2023 Jun;112(6):1715-1723. doi: 10.1016/j.xphs.2023.01.014. Epub 2023 Jan 20. J Pharm Sci. 2023. PMID: 36682487

5

In Vitro-In Vivo Extrapolation of Key Transporter Activity at the Blood-Brain Barrier.

Trapa PE, Troutman MD, Lau TY, Wager TT, Maurer TS, Patel NC, West MA, Umland JP, Carlo AA, Feng B, Liras JL. Trapa PE, et al. Drug Metab Dispos. 2019 Apr;47(4):405-411. doi: 10.1124/dmd.118.083279. Epub 2019 Jan 25. Drug Metab Dispos. 2019. PMID: 30683809

6

Prediction of Human Brain Penetration of P-glycoprotein and Breast Cancer Resistance Protein Substrates Using In Vitro Transporter Studies and Animal Models.

Feng B, Doran AC, Di L, West MA, Osgood SM, Mancuso JY, Shaffer CL, Tremaine L, Liras J. Feng B, et al. Among authors: west ma. J Pharm Sci. 2018 Aug;107(8):2225-2235. doi: 10.1016/j.xphs.2018.03.018. Epub 2018 Mar 30. J Pharm Sci. 2018. PMID: 29608887

7

In vitro characterization of axitinib interactions with human efflux and hepatic uptake transporters: implications for disposition and drug interactions.

Reyner EL, Sevidal S, West MA, Clouser-Roche A, Freiwald S, Fenner K, Ullah M, Lee CA, Smith BJ. Reyner EL, et al. Among authors: west ma. Drug Metab Dispos. 2013 Aug;41(8):1575-83. doi: 10.1124/dmd.113.051193. Epub 2013 May 31. Drug Metab Dispos. 2013. PMID: 23729661

8

Identification of Glycochenodeoxycholate 3-O-Glucuronide and Glycodeoxycholate 3-O-Glucuronide as Highly Sensitive and Specific OATP1B1 Biomarkers.

Neuvonen M, Hirvensalo P, Tornio A, Rago B, West M, Lazzaro S, Mathialagan S, Varma M, Cerny MA, Costales C, Ramanathan R, Rodrigues AD, Niemi M. Neuvonen M, et al. Among authors: west m. Clin Pharmacol Ther. 2021 Mar;109(3):646-657. doi: 10.1002/cpt.2053. Epub 2020 Oct 18. Clin Pharmacol Ther. 2021. PMID: 32961594 Free PMC article.

9

Mechanistic Determinants of Daprodustat Drug-Drug Interactions and Pharmacokinetics in Hepatic Dysfunction and Chronic Kidney Disease: Significance of OATP1B-CYP2C8 Interplay.

Bi YA, Jordan S, King-Ahmad A, West MA, Varma MVS. Bi YA, et al. Clin Pharmacol Ther. 2024 Jun;115(6):1336-1345. doi: 10.1002/cpt.3215. Epub 2024 Feb 26. Clin Pharmacol Ther. 2024. PMID: 38404228

10

Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes.

Bi YA, Costales C, Mathialagan S, West M, Eatemadpour S, Lazzaro S, Tylaska L, Scialis R, Zhang H, Umland J, Kimoto E, Tess DA, Feng B, Tremaine LM, Varma MVS, Rodrigues AD. Bi YA, et al. Among authors: west m. J Pharmacol Exp Ther. 2019 Jul;370(1):72-83. doi: 10.1124/jpet.119.257600. Epub 2019 Apr 11. J Pharmacol Exp Ther. 2019. PMID: 30975793

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