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Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice.
Guo S, Casu C, Gardenghi S, Booten S, Aghajan M, Peralta R, Watt A, Freier S, Monia BP, Rivella S. Guo S, et al. Among authors: rivella s. J Clin Invest. 2013 Apr;123(4):1531-41. doi: 10.1172/JCI66969. Epub 2013 Mar 25. J Clin Invest. 2013. PMID: 23524968 Free PMC article.
Correcting β-thalassemia by combined therapies that restrict iron and modulate erythropoietin activity.
Casu C, Pettinato M, Liu A, Aghajan M, Lo Presti V, Lidonnici MR, Munoz KA, O'Hara E, Olivari V, Di Modica SM, Booten S, Guo S, Neil G, Miari R, Shapir N, Zafir-Lavie I, Domev H, Ferrari G, Sitara D, Nai A, Rivella S. Casu C, et al. Among authors: rivella s. Blood. 2020 Oct 22;136(17):1968-1979. doi: 10.1182/blood.2019004719. Blood. 2020. PMID: 32556142 Free PMC article.
Tmprss6-ASO as a tool for the treatment of Polycythemia Vera mice.
Casu C, Liu A, De Rosa G, Low A, Suzuki A, Sinha S, Ginzburg YZ, Abrams C, Aghajan M, Guo S, Rivella S. Casu C, et al. Among authors: rivella s. PLoS One. 2021 Dec 10;16(12):e0251995. doi: 10.1371/journal.pone.0251995. eCollection 2021. PLoS One. 2021. PMID: 34890402 Free PMC article.
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice.
Gardenghi S, Ramos P, Marongiu MF, Melchiori L, Breda L, Guy E, Muirhead K, Rao N, Roy CN, Andrews NC, Nemeth E, Follenzi A, An X, Mohandas N, Ginzburg Y, Rachmilewitz EA, Giardina PJ, Grady RW, Rivella S. Gardenghi S, et al. Among authors: rivella s. J Clin Invest. 2010 Dec;120(12):4466-77. doi: 10.1172/JCI41717. Epub 2010 Nov 22. J Clin Invest. 2010. PMID: 21099112 Free PMC article.
Hepcidin agonists as therapeutic tools.
Casu C, Nemeth E, Rivella S. Casu C, et al. Among authors: rivella s. Blood. 2018 Apr 19;131(16):1790-1794. doi: 10.1182/blood-2017-11-737411. Epub 2018 Mar 9. Blood. 2018. PMID: 29523504 Free PMC article. Review.
158 results