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Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells.
Cosimo E, McCaig AM, Carter-Brzezinski LJ, Wheadon H, Leach MT, Le Ster K, Berthou C, Durieu E, Oumata N, Galons H, Meijer L, Michie AM. Cosimo E, et al. Among authors: galons h. Clin Cancer Res. 2013 May 1;19(9):2393-405. doi: 10.1158/1078-0432.CCR-12-2170. Epub 2013 Mar 26. Clin Cancer Res. 2013. PMID: 23532892
Targeting low molecular weight cyclin E (LMW-E) in breast cancer.
Nanos-Webb A, Jabbour NA, Multani AS, Wingate H, Oumata N, Galons H, Joseph B, Meijer L, Hunt KK, Keyomarsi K. Nanos-Webb A, et al. Among authors: galons h. Breast Cancer Res Treat. 2012 Apr;132(2):575-88. doi: 10.1007/s10549-011-1638-4. Epub 2011 Jun 22. Breast Cancer Res Treat. 2012. PMID: 21695458 Free PMC article.
Cyclin-dependent kinase inhibitors closer to market launch?
Galons H, Oumata N, Gloulou O, Meijer L. Galons H, et al. Expert Opin Ther Pat. 2013 Aug;23(8):945-63. doi: 10.1517/13543776.2013.789861. Epub 2013 Apr 22. Expert Opin Ther Pat. 2013. PMID: 23600454 Review.
CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.
Delehouzé C, Godl K, Loaëc N, Bruyère C, Desban N, Oumata N, Galons H, Roumeliotis TI, Giannopoulou EG, Grenet J, Twitchell D, Lahti J, Mouchet N, Galibert MD, Garbis SD, Meijer L. Delehouzé C, et al. Among authors: galons h. Oncogene. 2014 Dec 11;33(50):5675-87. doi: 10.1038/onc.2013.513. Epub 2013 Dec 9. Oncogene. 2014. PMID: 24317512 Free PMC article.
101 results