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Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS.
Flanagan K, Fitzgerald K, Baker J, Regnstrom K, Gardai S, Bard F, Mocci S, Seto P, You M, Larochelle C, Prat A, Chow S, Li L, Vandevert C, Zago W, Lorenzana C, Nishioka C, Hoffman J, Botelho R, Willits C, Tanaka K, Johnston J, Yednock T. Flanagan K, et al. Among authors: tanaka k. PLoS One. 2012;7(7):e40443. doi: 10.1371/journal.pone.0040443. Epub 2012 Jul 6. PLoS One. 2012. PMID: 22792325 Free PMC article.
Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Basi GS, Hemphill S, Brigham EF, Liao A, Aubele DL, Baker J, Barbour R, Bova M, Chen XH, Dappen MS, Eichenbaum T, Goldbach E, Hawkinson J, Lawler-Herbold R, Hu K, Hui T, Jagodzinski JJ, Keim PS, Kholodenko D, Latimer LH, Lee M, Marugg J, Mattson MN, McCauley S, Miller JL, Motter R, Mutter L, Neitzel ML, Ni H, Nguyen L, Quinn K, Ruslim L, Semko CM, Shapiro P, Smith J, Soriano F, Szoke B, Tanaka K, Tang P, Tucker JA, Ye XM, Yu M, Wu J, Xu YZ, Garofalo AW, Sauer JM, Konradi AW, Ness D, Shopp G, Pleiss MA, Freedman SB, Schenk D. Basi GS, et al. Among authors: tanaka k. Alzheimers Res Ther. 2010 Dec 29;2(6):36. doi: 10.1186/alzrt60. Alzheimers Res Ther. 2010. PMID: 21190552 Free PMC article.
Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.
Probst G, Aubele DL, Bowers S, Dressen D, Garofalo AW, Hom RK, Konradi AW, Marugg JL, Mattson MN, Neitzel ML, Semko CM, Sham HL, Smith J, Sun M, Truong AP, Ye XM, Xu YZ, Dappen MS, Jagodzinski JJ, Keim PS, Peterson B, Latimer LH, Quincy D, Wu J, Goldbach E, Ness DK, Quinn KP, Sauer JM, Wong K, Zhang H, Zmolek W, Brigham EF, Kholodenko D, Hu K, Kwong GT, Lee M, Liao A, Motter RN, Sacayon P, Santiago P, Willits C, Bard F, Bova MP, Hemphill SS, Nguyen L, Ruslim L, Tanaka K, Tanaka P, Wallace W, Yednock TA, Basi GS. Probst G, et al. Among authors: tanaka k, tanaka p. J Med Chem. 2013 Jul 11;56(13):5261-74. doi: 10.1021/jm301741t. Epub 2013 Jun 20. J Med Chem. 2013. PMID: 23713656
Ethiodized Oil Pickering Emulsion for Sustained Release of Anti-PD-L1 Antibodies.
Satomura H, Kimura Y, Kennoki N, Tomotake K, Yano H, Koretsune Y, Katayama D, Tanaka K, Ono Y, Higashihara H, Tomiyama N. Satomura H, et al. Among authors: tanaka k. J Vasc Interv Radiol. 2025 Jan 23:S1051-0443(25)00134-4. doi: 10.1016/j.jvir.2025.01.040. Online ahead of print. J Vasc Interv Radiol. 2025. PMID: 39863284
Efficacy and safety of first-line targeted synthetic DMARDs in rheumatoid arthritis patients with chronic kidney disease.
Yoshimura Y, Yamanouchi M, Koizumi R, Mizuno H, Oba Y, Kurihara S, Suwabe T, Tsunoda S, Kishioka A, Takeuchi T, Tanimizu H, Kamido H, Yoshimoto M, Sugimoto H, Ikuma D, Tanaka K, Inoue N, Sekine A, Hasegawa E, Wada T, Ubara Y, Sawa N. Yoshimura Y, et al. Among authors: tanaka k. Rheumatology (Oxford). 2025 Jan 25:keaf050. doi: 10.1093/rheumatology/keaf050. Online ahead of print. Rheumatology (Oxford). 2025. PMID: 39862405
Apoptosis in Cancer Biology and Therapy.
Moyer A, Tanaka K, Cheng EH. Moyer A, et al. Among authors: tanaka k. Annu Rev Pathol. 2025 Jan;20(1):303-328. doi: 10.1146/annurev-pathmechdis-051222-115023. Annu Rev Pathol. 2025. PMID: 39854189 Review.
Adjuvant Chemotherapy After Resection of Localized Pancreatic Adenocarcinoma Following Preoperative FOLFIRINOX.
Stoop TF, Sugawara T, Oba A, Feld IM, van Roessel S, van Veldhuisen E, Wu YHA, Nishino J, Ali M, Alseidi A, Sauvanet A, Mirabella A, Sa Cunha A, Kokkola A, Groot Koerkamp B, Pietrasz D, Kleive D, Butturini G, Malleo G, van Laarhoven HWM, Frigerio I, Dembinski J, He J, Gagnière J, Kleeff J, Ramia JM, Roberts KJ, Labori KJ, Marino MV, Falconi M, B Mortensen M, Lesurtel M, Bonds M, Chatzizacharias N, Strobel O, Turrini O, Griffin O, Franklin O, Pfeiffer P, Schulick RD, Salvia R, de Wilde RF, Dokmak S, Rodriguez Franco S, Augustinus S, Burgdorf SK, Crippa S, Hackert T, Tarvainen T, Burns WR, Messersmith W, Wilmink JW, Burkhart RA, Del Chiaro M, Besselink MG; Scientific Committee of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA) and International Collaboration on Advanced Pancreatic Cancer. Stoop TF, et al. JAMA Oncol. 2025 Jan 23. doi: 10.1001/jamaoncol.2024.5917. Online ahead of print. JAMA Oncol. 2025. PMID: 39847363
Indications for chemoradiotherapy in older patients with locally advanced head and neck cancer in Japan: a questionnaire survey in the JCOG head and neck cancer study group.
Yasuda K, Kiyota N, Matsuura K, Saito S, Honma Y, Imamura Y, Tanaka K, Zenda S, Onoe T, Kodaira T, Kobayashi S, Aoyama H, Hanai N, Homma A. Yasuda K, et al. Among authors: tanaka k. Front Oncol. 2025 Jan 8;14:1441056. doi: 10.3389/fonc.2024.1441056. eCollection 2024. Front Oncol. 2025. PMID: 39845314 Free PMC article.
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