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Page 1
Hepatitis C replication inhibitors that target the viral NS4B protein.
Miller JF, Chong PY, Shotwell JB, Catalano JG, Tai VW, Fang J, Banka AL, Roberts CD, Youngman M, Zhang H, Xiong Z, Mathis A, Pouliot JJ, Hamatake RK, Price DJ, Seal JW 3rd, Stroup LL, Creech KL, Carballo LH, Todd D, Spaltenstein A, Furst S, Hong Z, Peat AJ. Miller JF, et al. Among authors: spaltenstein a. J Med Chem. 2014 Mar 13;57(5):2107-20. doi: 10.1021/jm400125h. Epub 2013 Apr 19. J Med Chem. 2014. PMID: 23544424
Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.
Maynard A, Crosby RM, Ellis B, Hamatake R, Hong Z, Johns BA, Kahler KM, Koble C, Leivers A, Leivers MR, Mathis A, Peat AJ, Pouliot JJ, Roberts CD, Samano V, Schmidt RM, Smith GK, Spaltenstein A, Stewart EL, Thommes P, Turner EM, Voitenleitner C, Walker JT, Waitt G, Weatherhead J, Weaver K, Williams S, Wright L, Xiong ZZ, Haigh D, Shotwell JB. Maynard A, et al. Among authors: spaltenstein a. J Med Chem. 2014 Mar 13;57(5):1902-13. doi: 10.1021/jm400317w. Epub 2013 May 29. J Med Chem. 2014. PMID: 23672667
Discovery of next generation inhibitors of HIV protease.
Spaltenstein A, Kazmierski WM, Miller JF, Samano V. Spaltenstein A, et al. Curr Top Med Chem. 2005;5(16):1589-607. doi: 10.2174/156802605775009694. Curr Top Med Chem. 2005. PMID: 16375744 Review.
Substituted tetrahydrocarbazoles with potent activity against human papillomaviruses.
Gudmundsson KS, Sebahar PR, Richardson LD, Catalano JG, Boggs SD, Spaltenstein A, Sethna PB, Brown KW, Harvey R, Romines KR. Gudmundsson KS, et al. Among authors: spaltenstein a. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3489-92. doi: 10.1016/j.bmcl.2009.05.003. Epub 2009 May 7. Bioorg Med Chem Lett. 2009. PMID: 19457669
Amine substituted N-(1H-benzimidazol-2ylmethyl)-5,6,7,8-tetrahydro-8-quinolinamines as CXCR4 antagonists with potent activity against HIV-1.
Gudmundsson KS, Sebahar PR, Richardson LD, Miller JF, Turner EM, Catalano JG, Spaltenstein A, Lawrence W, Thomson M, Jenkinson S. Gudmundsson KS, et al. Among authors: spaltenstein a. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5048-52. doi: 10.1016/j.bmcl.2009.07.037. Epub 2009 Jul 10. Bioorg Med Chem Lett. 2009. PMID: 19640718
Synthesis of a novel tricyclic 1,2,3,4,4a,5,6,10b-octahydro-1,10-phenanthroline ring system and CXCR4 antagonists with potent activity against HIV-1.
Catalano JG, Gudmundsson KS, Svolto A, Boggs SD, Miller JF, Spaltenstein A, Thomson M, Wheelan P, Minick DJ, Phelps DP, Jenkinson S. Catalano JG, et al. Among authors: spaltenstein a. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2186-90. doi: 10.1016/j.bmcl.2010.02.030. Epub 2010 Feb 12. Bioorg Med Chem Lett. 2010. PMID: 20194023
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