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A highly concise and convergent synthesis of HCV polymerase inhibitor Deleobuvir (BI 207127): application of a one-pot borylation-Suzuki coupling reaction.
Zhang Y, Lu BZ, Li G, Rodriguez S, Tan J, Wei HX, Liu J, Roschangar F, Ding F, Zhao W, Qu B, Reeves D, Grinberg N, Lee H, Heckmann G, Niemeier O, Brenner M, Tsantrizos Y, Beaulieu PL, Hossain A, Yee N, Farina V, Senanayake CH. Zhang Y, et al. Among authors: senanayake ch. Org Lett. 2014 Sep 5;16(17):4558-61. doi: 10.1021/ol5021114. Epub 2014 Aug 8. Org Lett. 2014. PMID: 25105303
An Enantioselective Synthesis of an 11-β-HSD-1 Inhibitor via an Asymmetric Methallylation Catalyzed by (S)-3,3'-F2-BINOL.
Zhang Y, Wu JP, Li G, Fandrick KR, Gao J, Tan Z, Johnson J, Li W, Sanyal S, Wang J, Sun X, Lorenz JC, Rodriguez S, Reeves JT, Grinberg N, Lee H, Yee N, Lu BZ, Senanayake CH. Zhang Y, et al. Among authors: senanayake ch. J Org Chem. 2016 Mar 18;81(6):2665-9. doi: 10.1021/acs.joc.6b00189. Epub 2016 Mar 2. J Org Chem. 2016. PMID: 26909738
173 results