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631 results

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Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.
Coffee EM, Faber AC, Roper J, Sinnamon MJ, Goel G, Keung L, Wang WV, Vecchione L, de Vriendt V, Weinstein BJ, Bronson RT, Tejpar S, Xavier RJ, Engelman JA, Martin ES, Hung KE. Coffee EM, et al. Among authors: xavier rj. Clin Cancer Res. 2013 May 15;19(10):2688-98. doi: 10.1158/1078-0432.CCR-12-2556. Epub 2013 Apr 2. Clin Cancer Res. 2013. PMID: 23549875 Free PMC article.
Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.
Martin ES, Belmont PJ, Sinnamon MJ, Richard LG, Yuan J, Coffee EM, Roper J, Lee L, Heidari P, Lunt SY, Goel G, Ji X, Xie Z, Xie T, Lamb J, Weinrich SL, VanArsdale T, Bronson RT, Xavier RJ, Vander Heiden MG, Kan JL, Mahmood U, Hung KE. Martin ES, et al. Among authors: xavier rj. Clin Cancer Res. 2013 Jun 1;19(11):2929-40. doi: 10.1158/1078-0432.CCR-12-2307. Epub 2013 Feb 12. Clin Cancer Res. 2013. PMID: 23403635 Free PMC article.
Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.
Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ. Conway KL, et al. Among authors: xavier rj. Gastroenterology. 2013 Dec;145(6):1347-57. doi: 10.1053/j.gastro.2013.08.035. Epub 2013 Aug 21. Gastroenterology. 2013. PMID: 23973919 Free PMC article.
Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.
Shaw SY, Tran K, Castoreno AB, Peloquin JM, Lassen KG, Khor B, Aldrich LN, Tan PH, Graham DB, Kuballa P, Goel G, Daly MJ, Shamji AF, Schreiber SL, Xavier RJ. Shaw SY, et al. Among authors: xavier rj. ACS Chem Biol. 2013 Dec 20;8(12):2724-2733. doi: 10.1021/cb400352d. Epub 2013 Oct 29. ACS Chem Biol. 2013. PMID: 24168452 Free PMC article.
Discovery of a Small-Molecule Probe for V-ATPase Function.
Aldrich LN, Kuo SY, Castoreno AB, Goel G, Kuballa P, Rees MG, Seashore-Ludlow BA, Cheah JH, Latorre IJ, Schreiber SL, Shamji AF, Xavier RJ. Aldrich LN, et al. Among authors: xavier rj. J Am Chem Soc. 2015 Apr 29;137(16):5563-8. doi: 10.1021/jacs.5b02150. Epub 2015 Apr 20. J Am Chem Soc. 2015. PMID: 25860544 Free PMC article.
The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells.
Khor B, Gagnon JD, Goel G, Roche MI, Conway KL, Tran K, Aldrich LN, Sundberg TB, Paterson AM, Mordecai S, Dombkowski D, Schirmer M, Tan PH, Bhan AK, Roychoudhuri R, Restifo NP, O'Shea JJ, Medoff BD, Shamji AF, Schreiber SL, Sharpe AH, Shaw SY, Xavier RJ. Khor B, et al. Among authors: xavier rj. Elife. 2015 May 22;4:e05920. doi: 10.7554/eLife.05920. Elife. 2015. PMID: 25998054 Free PMC article.
631 results