Shuto S - Search Results

1

Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring.

Yonezawa S, Yamakawa H, Muto C, Hosono M, Yamamoto T, Hattori K, Sakagami M, Togame H, Tanaka Y, Nakano T, Takemoto H, Arisawa M, Shuto S. Yonezawa S, et al. Among authors: shuto s. Bioorg Med Chem Lett. 2013 May 15;23(10):2912-5. doi: 10.1016/j.bmcl.2013.03.056. Epub 2013 Mar 26. Bioorg Med Chem Lett. 2013. PMID: 23562056

2

Nucleosides and nucleotides--CXXXVII. Antitumor phospholipids with 5-fluorouridine as a cytotoxic polar-head: synthesis of 5'-phosphatidyl-5-fluorouridines by phospholipase D-catalyzed transphosphatidylation.

Shuto S, Itoh H, Sakai A, Nakagami K, Imamura S, Matsuda A. Shuto S, et al. Bioorg Med Chem. 1995 Mar;3(3):235-43. doi: 10.1016/0968-0896(95)00003-y. Bioorg Med Chem. 1995. PMID: 7606385

3

(+/-)-(Z)-2-(aminomethyl)-1-phenylcyclopropanecarboxamide derivatives as a new prototype of NMDA receptor antagonists.

Shuto S, Takada H, Mochizuki D, Tsujita R, Hase Y, Ono S, Shibuya N, Matsuda A. Shuto S, et al. J Med Chem. 1995 Jul 21;38(15):2964-8. doi: 10.1021/jm00015a019. J Med Chem. 1995. PMID: 7636857

4

Synthesis and biological activity of conformationally restricted analogs of milnacipran: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-diethylcyclopropanecarboxami de, an efficient noncompetitive N-methyl-D-aspartic acid receptor antagonist.

Shuto S, Ono S, Hase Y, Ueno Y, Noguchi T, Yoshii K, Matsuda A. Shuto S, et al. J Med Chem. 1996 Nov 22;39(24):4844-52. doi: 10.1021/jm960495w. J Med Chem. 1996. PMID: 8941398

5

Nucleosides and nucleotides. 175. Structural requirements of the sugar moiety for the antitumor activities of new nucleoside antimetabolites, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine and -uracil1.

Hattori H, Nozawa E, Iino T, Yoshimura Y, Shuto S, Shimamoto Y, Nomura M, Fukushima M, Tanaka M, Sasaki T, Matsuda A. Hattori H, et al. Among authors: shuto s. J Med Chem. 1998 Jul 16;41(15):2892-902. doi: 10.1021/jm9801814. J Med Chem. 1998. PMID: 9667977

6

Synthesis and biological activity of conformationally restricted analogues of milnacipran: (1S, 2R)-1-phenyl-2-[(R)-1-amino-2-propynyl]-N,N- diethylcyclopropanecarboxamide is a novel class of NMDA receptor channel blocker.

Shuto S, Ono S, Imoto H, Yoshii K, Matsuda A. Shuto S, et al. J Med Chem. 1998 Aug 27;41(18):3507-14. doi: 10.1021/jm980238m. J Med Chem. 1998. PMID: 9719604

7

Nucleosides and nucleotides. 185. Synthesis and biological activities of 4'alpha-C-branched-chain sugar pyrimidine nucleosides.

Nomura M, Shuto S, Tanaka M, Sasaki T, Mori S, Shigeta S, Matsuda A. Nomura M, et al. Among authors: shuto s. J Med Chem. 1999 Jul 29;42(15):2901-8. doi: 10.1021/jm990050i. J Med Chem. 1999. PMID: 10425099

8

Total synthesis of cyclic ADP-carbocyclic-ribose, a stable mimic of Ca2+-mobilizing second messenger cyclic ADP-ribose.

Shuto S, Fukuoka M, Manikowsky A, Ueno Y, Nakano T, Kuroda R, Kuroda H, Matsuda A. Shuto S, et al. J Am Chem Soc. 2001 Sep 12;123(36):8750-9. doi: 10.1021/ja010756d. J Am Chem Soc. 2001. PMID: 11535079

9

New neplanocin analogues. 12. Alternative synthesis and antimalarial effect of (6'R)-6'-C-methylneplanocin A, a potent AdoHcy hydrolase inhibitor.

Shuto S, Minakawa N, Niizuma S, Kim HS, Wataya Y, Matsuda A. Shuto S, et al. J Med Chem. 2002 Jan 31;45(3):748-51. doi: 10.1021/jm010374i. J Med Chem. 2002. PMID: 11806727

10

Development of versatile cis- and trans-dicarbon-substituted chiral cyclopropane units: synthesis of (1S,2R)- and (1R,2R)-2-aminomethyl-1-(1H-imidazol-4-yl)cyclopropanes and their enantiomers as conformationally restricted analogues of histamine.

Kazuta Y, Matsuda A, Shuto S. Kazuta Y, et al. Among authors: shuto s. J Org Chem. 2002 Mar 8;67(5):1669-77. doi: 10.1021/jo010852x. J Org Chem. 2002. PMID: 11871901

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