Guan H - Search Results

1

Discovery of novel Jak2-Stat pathway inhibitors with extended residence time on target.

Guan H, Lamb ML, Peng B, Huang S, Degrace N, Read J, Hussain S, Wu J, Rivard C, Alimzhanov M, Bebernitz G, Bell K, Ye M, Zinda M, Ioannidis S. Guan H, et al. Bioorg Med Chem Lett. 2013 May 15;23(10):3105-10. doi: 10.1016/j.bmcl.2013.02.111. Epub 2013 Mar 7. Bioorg Med Chem Lett. 2013. PMID: 23562594

2

Replacement of pyrazol-3-yl amine hinge binder with thiazol-2-yl amine: Discovery of potent and selective JAK2 inhibitors.

Ioannidis S, Lamb ML, Almeida L, Guan H, Peng B, Bebernitz G, Bell K, Alimzhanov M, Zinda M. Ioannidis S, et al. Among authors: guan h. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1669-73. doi: 10.1016/j.bmcl.2010.01.091. Epub 2010 Jan 25. Bioorg Med Chem Lett. 2010. PMID: 20144546

3

Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.

Johannes JW, Almeida L, Daly K, Ferguson AD, Grosskurth SE, Guan H, Howard T, Ioannidis S, Kazmirski S, Lamb ML, Larsen NA, Lyne PD, Mikule K, Ogoe C, Peng B, Petteruti P, Read JA, Su N, Sylvester M, Throner S, Wang W, Wang X, Wu J, Ye Q, Yu Y, Zheng X, Scott DA. Johannes JW, et al. Among authors: guan h. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5743-7. doi: 10.1016/j.bmcl.2015.10.079. Epub 2015 Oct 27. Bioorg Med Chem Lett. 2015. PMID: 26546219

4

Design and synthesis of aminopropyl tetrahydroindole-based indolin-2-ones as selective and potent inhibitors of Src and Yes tyrosine kinase.

Guan H, Laird AD, Blake RA, Tang C, Liang C. Guan H, et al. Bioorg Med Chem Lett. 2004 Jan 5;14(1):187-90. doi: 10.1016/j.bmcl.2003.09.069. Bioorg Med Chem Lett. 2004. PMID: 14684325

5

Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS.

Schenck Eidam H, Russell J, Raha K, DeMartino M, Qin D, Guan HA, Zhang Z, Zhen G, Yu H, Wu C, Pan Y, Joberty G, Zinn N, Laquerre S, Robinson S, White A, Giddings A, Mohammadi E, Greenwood-Van Meerveld B, Oliff A, Kumar S, Cheung M. Schenck Eidam H, et al. Among authors: guan ha. ACS Med Chem Lett. 2018 May 24;9(7):623-628. doi: 10.1021/acsmedchemlett.8b00035. eCollection 2018 Jul 12. ACS Med Chem Lett. 2018. PMID: 30034590 Free PMC article.

6

SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity.

Patyna S, Laird AD, Mendel DB, O'farrell AM, Liang C, Guan H, Vojkovsky T, Vasile S, Wang X, Chen J, Grazzini M, Yang CY, Haznedar JO, Sukbuntherng J, Zhong WZ, Cherrington JM, Hu-Lowe D. Patyna S, et al. Among authors: guan h. Mol Cancer Ther. 2006 Jul;5(7):1774-82. doi: 10.1158/1535-7163.MCT-05-0333. Mol Cancer Ther. 2006. PMID: 16891463

7

Ralationship between polymorphisms and diplotypes of HLA-G 3'UTR and fetuses with abnormal chromosomes or unexplained pregnancy loss (UPL).

Xu D, Zhu Y, Wang J, Guan H, Shen X. Xu D, et al. Among authors: guan h. Hum Genomics. 2024 Nov 17;18(1):126. doi: 10.1186/s40246-024-00695-5. Hum Genomics. 2024. PMID: 39551809 Free PMC article.

8

Homozygous missense variations of APC12 cause meiotic metaphase I arrest in oocytes and female infertility.

Lin Y, Wei Z, Zhang L, Yao Y, Huang Y, Yao G, Wang W, Hu S, Ding Y, Lu Y, Bian X, Dong X, Guan H, Huang Y, Sun Y. Lin Y, et al. Among authors: guan h. Am J Obstet Gynecol. 2024 Nov 12:S0002-9378(24)01140-2. doi: 10.1016/j.ajog.2024.11.013. Online ahead of print. Am J Obstet Gynecol. 2024. PMID: 39542389

9

Tunable band-stop fiber filter based on laser-induced graphene metamaterial in THz frequency.

Tian Z, Luo Z, Lv X, Xie M, Peng G, Kong D, Lu H, Guan H. Tian Z, et al. Among authors: guan h. Opt Express. 2024 Jul 1;32(14):24251-24261. doi: 10.1364/OE.527472. Opt Express. 2024. PMID: 39538870 Free article.

10

Exosomal PSM-E inhibits macrophage M2 polarization to suppress prostate cancer metastasis through the RACK1 signaling axis.

Qin X, Niu R, Tan Y, Huang Y, Ren W, Zhou W, Wu H, Zhang J, Xu M, Zhou X, Guan H, Zhu X, Chen Y, Cao K. Qin X, et al. Among authors: guan h. Biomark Res. 2024 Nov 14;12(1):138. doi: 10.1186/s40364-024-00685-8. Biomark Res. 2024. PMID: 39538297 Free PMC article.

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