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Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer.
Castro E, Goh C, Olmos D, Saunders E, Leongamornlert D, Tymrakiewicz M, Mahmud N, Dadaev T, Govindasami K, Guy M, Sawyer E, Wilkinson R, Ardern-Jones A, Ellis S, Frost D, Peock S, Evans DG, Tischkowitz M, Cole T, Davidson R, Eccles D, Brewer C, Douglas F, Porteous ME, Donaldson A, Dorkins H, Izatt L, Cook J, Hodgson S, Kennedy MJ, Side LE, Eason J, Murray A, Antoniou AC, Easton DF, Kote-Jarai Z, Eeles R. Castro E, et al. J Clin Oncol. 2013 May 10;31(14):1748-57. doi: 10.1200/JCO.2012.43.1882. Epub 2013 Apr 8. J Clin Oncol. 2013. PMID: 23569316 Free PMC article.
The frequency of germ-line mutations in the breast cancer predisposition genes BRCA1 and BRCA2 in familial prostate cancer. The Cancer Research Campaign/British Prostate Group United Kingdom Familial Prostate Cancer Study Collaborators.
Gayther SA, de Foy KA, Harrington P, Pharoah P, Dunsmuir WD, Edwards SM, Gillett C, Ardern-Jones A, Dearnaley DP, Easton DF, Ford D, Shearer RJ, Kirby RS, Dowe AL, Kelly J, Stratton MR, Ponder BA, Barnes D, Eeles RA. Gayther SA, et al. Cancer Res. 2000 Aug 15;60(16):4513-8. Cancer Res. 2000. PMID: 10969800
Forum for Applied Cancer Education and Training (FACET).
Ardern-Jones A, Eeles R. Ardern-Jones A, et al. Eur J Cancer Care (Engl). 2002 Mar;11(1):63-8. doi: 10.1046/j.1365-2354.2002.t01-1-00306.x. Eur J Cancer Care (Engl). 2002. PMID: 11966837 No abstract available.
HPC2/ELAC2 polymorphisms and prostate cancer risk: analysis by age of onset of disease.
Meitz JC, Edwards SM, Easton DF, Murkin A, Ardern-Jones A, Jackson RA, Williams S, Dearnaley DP, Stratton MR, Houlston RS, Eeles RA; Cancer Research UK/BPG UK Familial Prostate Cancer Study Collaborators. Meitz JC, et al. Br J Cancer. 2002 Oct 7;87(8):905-8. doi: 10.1038/sj.bjc.6600564. Br J Cancer. 2002. PMID: 12373607 Free PMC article.
Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene.
Edwards SM, Kote-Jarai Z, Meitz J, Hamoudi R, Hope Q, Osin P, Jackson R, Southgate C, Singh R, Falconer A, Dearnaley DP, Ardern-Jones A, Murkin A, Dowe A, Kelly J, Williams S, Oram R, Stevens M, Teare DM, Ponder BA, Gayther SA, Easton DF, Eeles RA; Cancer Research UK/Bristish Prostate Group UK Familial Prostate Cancer Study Collaborators; British Association of Urological Surgeons Section of Oncology. Edwards SM, et al. Am J Hum Genet. 2003 Jan;72(1):1-12. doi: 10.1086/345310. Epub 2002 Dec 9. Am J Hum Genet. 2003. PMID: 12474142 Free PMC article.
Association between the GCG polymorphism of the selenium dependent GPX1 gene and the risk of young onset prostate cancer.
Kote-Jarai Z, Durocher F, Edwards SM, Hamoudi R, Jackson RA, Ardern-Jones A, Murkin A, Dearnaley DP, Kirby R, Houlston R, Easton DF, Eeles R; CRC/BPG UK Familial Prostrate Cancer Collaborators. Kote-Jarai Z, et al. Prostate Cancer Prostatic Dis. 2002;5(3):189-92. doi: 10.1038/sj.pcan.4500569. Prostate Cancer Prostatic Dis. 2002. PMID: 12496980
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