Murphy MP - Search Results

1

Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism.

Mourtada R, Fonseca SB, Wisnovsky SP, Pereira MP, Wang X, Hurren R, Parfitt J, Larsen L, Smith RA, Murphy MP, Schimmer AD, Kelley SO. Mourtada R, et al. Among authors: murphy mp. PLoS One. 2013 Apr 9;8(4):e60253. doi: 10.1371/journal.pone.0060253. Print 2013. PLoS One. 2013. PMID: 23585833 Free PMC article.

2

Synthesis and characterization of thiobutyltriphenylphosphonium bromide, a novel thiol reagent targeted to the mitochondrial matrix.

Burns RJ, Smith RA, Murphy MP. Burns RJ, et al. Among authors: murphy mp. Arch Biochem Biophys. 1995 Sep 10;322(1):60-8. doi: 10.1006/abbi.1995.1436. Arch Biochem Biophys. 1995. PMID: 7574695

3

Selective targeting of an antioxidant to mitochondria.

Smith RA, Porteous CM, Coulter CV, Murphy MP. Smith RA, et al. Among authors: murphy mp. Eur J Biochem. 1999 Aug;263(3):709-16. doi: 10.1046/j.1432-1327.1999.00543.x. Eur J Biochem. 1999. PMID: 10469134 Free article.

4

Drug delivery to mitochondria: the key to mitochondrial medicine.

Murphy MP, Smith RA. Murphy MP, et al. Adv Drug Deliv Rev. 2000 Mar 30;41(2):235-50. doi: 10.1016/s0169-409x(99)00069-1. Adv Drug Deliv Rev. 2000. PMID: 10699318 Review.

5

Mitochondrially targeted antioxidants and thiol reagents.

Coulter CV, Kelso GF, Lin TK, Smith RA, Murphy MP. Coulter CV, et al. Among authors: murphy mp. Free Radic Biol Med. 2000 May 15;28(10):1547-54. doi: 10.1016/s0891-5849(00)00255-0. Free Radic Biol Med. 2000. PMID: 10927180 Review.

6

Prevention of mitochondrial oxidative damage using targeted antioxidants.

Kelso GF, Porteous CM, Hughes G, Ledgerwood EC, Gane AM, Smith RA, Murphy MP. Kelso GF, et al. Among authors: murphy mp. Ann N Y Acad Sci. 2002 Apr;959:263-74. doi: 10.1111/j.1749-6632.2002.tb02098.x. Ann N Y Acad Sci. 2002. PMID: 11976201

7

Delivery of bioactive molecules to mitochondria in vivo.

Smith RA, Porteous CM, Gane AM, Murphy MP. Smith RA, et al. Among authors: murphy mp. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5407-12. doi: 10.1073/pnas.0931245100. Epub 2003 Apr 15. Proc Natl Acad Sci U S A. 2003. PMID: 12697897 Free PMC article.

8

Specific targeting of a DNA-alkylating reagent to mitochondria. Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide.

James AM, Blaikie FH, Smith RA, Lightowlers RN, Smith PM, Murphy MP. James AM, et al. Among authors: murphy mp. Eur J Biochem. 2003 Jul;270(13):2827-36. doi: 10.1046/j.1432-1033.2003.03660.x. Eur J Biochem. 2003. PMID: 12823553 Free article.

9

Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants.

Jauslin ML, Meier T, Smith RA, Murphy MP. Jauslin ML, et al. Among authors: murphy mp. FASEB J. 2003 Oct;17(13):1972-4. doi: 10.1096/fj.03-0240fje. Epub 2003 Aug 15. FASEB J. 2003. PMID: 12923074

10

Delivery of antisense peptide nucleic acids (PNAs) to the cytosol by disulphide conjugation to a lipophilic cation.

Filipovska A, Eccles MR, Smith RA, Murphy MP. Filipovska A, et al. Among authors: murphy mp. FEBS Lett. 2004 Jan 2;556(1-3):180-6. doi: 10.1016/s0014-5793(03)01403-0. FEBS Lett. 2004. PMID: 14706847 Free article.

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