Smith RA - Search Results

1

Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism.

Mourtada R, Fonseca SB, Wisnovsky SP, Pereira MP, Wang X, Hurren R, Parfitt J, Larsen L, Smith RA, Murphy MP, Schimmer AD, Kelley SO. Mourtada R, et al. Among authors: smith ra. PLoS One. 2013 Apr 9;8(4):e60253. doi: 10.1371/journal.pone.0060253. Print 2013. PLoS One. 2013. PMID: 23585833 Free PMC article.

2

Targeting antioxidants to mitochondria by conjugation to lipophilic cations.

Murphy MP, Smith RA. Murphy MP, et al. Among authors: smith ra. Annu Rev Pharmacol Toxicol. 2007;47:629-56. doi: 10.1146/annurev.pharmtox.47.120505.105110. Annu Rev Pharmacol Toxicol. 2007. PMID: 17014364 Review.

3

Mitochondria-targeted antioxidants as therapies.

Smith RA, Murphy MP. Smith RA, et al. Discov Med. 2011 Feb;11(57):106-14. Discov Med. 2011. PMID: 21356165 Free article. Review.

4

Animal and human studies with the mitochondria-targeted antioxidant MitoQ.

Smith RA, Murphy MP. Smith RA, et al. Ann N Y Acad Sci. 2010 Jul;1201:96-103. doi: 10.1111/j.1749-6632.2010.05627.x. Ann N Y Acad Sci. 2010. PMID: 20649545 Review.

5

Mitochondria-targeted small molecule therapeutics and probes.

Smith RA, Hartley RC, Murphy MP. Smith RA, et al. Antioxid Redox Signal. 2011 Dec 15;15(12):3021-38. doi: 10.1089/ars.2011.3969. Epub 2011 Jun 6. Antioxid Redox Signal. 2011. PMID: 21395490 Review.

6

A mitochondria-targeted derivative of ascorbate: MitoC.

Finichiu PG, Larsen DS, Evans C, Larsen L, Bright TP, Robb EL, Trnka J, Prime TA, James AM, Smith RA, Murphy MP. Finichiu PG, et al. Among authors: smith ra. Free Radic Biol Med. 2015 Dec;89:668-78. doi: 10.1016/j.freeradbiomed.2015.07.160. Epub 2015 Oct 8. Free Radic Biol Med. 2015. PMID: 26453920 Free PMC article.

7

Mitochondrial pharmacology.

Smith RA, Hartley RC, Cochemé HM, Murphy MP. Smith RA, et al. Trends Pharmacol Sci. 2012 Jun;33(6):341-52. doi: 10.1016/j.tips.2012.03.010. Epub 2012 Apr 18. Trends Pharmacol Sci. 2012. PMID: 22521106 Free article. Review.

8

Mitochondrial accumulation of a lipophilic cation conjugated to an ionisable group depends on membrane potential, pH gradient and pK(a): implications for the design of mitochondrial probes and therapies.

Finichiu PG, James AM, Larsen L, Smith RA, Murphy MP. Finichiu PG, et al. Among authors: smith ra. J Bioenerg Biomembr. 2013 Feb;45(1-2):165-73. doi: 10.1007/s10863-012-9493-5. Epub 2012 Nov 22. J Bioenerg Biomembr. 2013. PMID: 23180142

9

Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy.

Graham D, Huynh NN, Hamilton CA, Beattie E, Smith RA, Cochemé HM, Murphy MP, Dominiczak AF. Graham D, et al. Among authors: smith ra. Hypertension. 2009 Aug;54(2):322-8. doi: 10.1161/HYPERTENSIONAHA.109.130351. Epub 2009 Jul 6. Hypertension. 2009. PMID: 19581509

10

Specific targeting of a DNA-alkylating reagent to mitochondria. Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide.

James AM, Blaikie FH, Smith RA, Lightowlers RN, Smith PM, Murphy MP. James AM, et al. Among authors: smith ra, smith pm. Eur J Biochem. 2003 Jul;270(13):2827-36. doi: 10.1046/j.1432-1033.2003.03660.x. Eur J Biochem. 2003. PMID: 12823553 Free article.

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