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Adenosine signaling, priapism and novel therapies.
Dai Y, Zhang Y, Phatarpekar P, Mi T, Zhang H, Blackburn MR, Xia Y. Dai Y, et al. Among authors: xia y. J Sex Med. 2009 Mar;6 Suppl 3:292-301. doi: 10.1111/j.1743-6109.2008.01187.x. J Sex Med. 2009. PMID: 19267852 Review.
Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling.
Wen J, Jiang X, Dai Y, Zhang Y, Tang Y, Sun H, Mi T, Phatarpekar PV, Kellems RE, Blackburn MR, Xia Y. Wen J, et al. Among authors: xia y. FASEB J. 2010 Mar;24(3):740-9. doi: 10.1096/fj.09-144147. Epub 2009 Oct 26. FASEB J. 2010. PMID: 19858092 Free PMC article.
Overall, our studies identify an essential role of increased adenosine in the pathogenesis of penile fibrosis via A(2B)R signaling and offer a potential target for prevention and treatment of penile fibrosis, a dangerous complication seen in priapism.-Wen, J., Jiang, X., Dai, …
Overall, our studies identify an essential role of increased adenosine in the pathogenesis of penile fibrosis via A(2B)R signaling and offer …
Detrimental effects of adenosine signaling in sickle cell disease.
Zhang Y, Dai Y, Wen J, Zhang W, Grenz A, Sun H, Tao L, Lu G, Alexander DC, Milburn MV, Carter-Dawson L, Lewis DE, Zhang W, Eltzschig HK, Kellems RE, Blackburn MR, Juneja HS, Xia Y. Zhang Y, et al. Among authors: xia y. Nat Med. 2011 Jan;17(1):79-86. doi: 10.1038/nm.2280. Epub 2010 Dec 19. Nat Med. 2011. PMID: 21170046 Free PMC article.
Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice.
Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK. Grenz A, et al. Among authors: xia y. J Clin Invest. 2012 Feb;122(2):693-710. doi: 10.1172/JCI60214. Epub 2012 Jan 24. J Clin Invest. 2012. Retraction in: J Clin Invest. 2017 Jun 1;127(6):2438. doi: 10.1172/JCI94890 PMID: 22269324 Free PMC article. Retracted.
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