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Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site.
Chen T, Kocinsky HS, Cha B, Murtazina R, Yang J, Tse CM, Singh V, Cole R, Aronson PS, de Jonge H, Sarker R, Donowitz M. Chen T, et al. Among authors: yang j. J Biol Chem. 2015 Jan 23;290(4):1952-65. doi: 10.1074/jbc.M114.590174. Epub 2014 Dec 5. J Biol Chem. 2015. PMID: 25480791 Free PMC article.
NHERF3 is necessary for Escherichia coli heat-stable enterotoxin-induced inhibition of NHE3: differences in signaling in mouse small intestine and Caco-2 cells.
Chen T, Lin R, Avula L, Sarker R, Yang J, Cha B, Tse CM, McNamara G, Seidler U, Waldman S, Snook A, Bijvelds MJC, de Jonge HR, Li X, Donowitz M. Chen T, et al. Among authors: yang j. Am J Physiol Cell Physiol. 2019 Oct 1;317(4):C737-C748. doi: 10.1152/ajpcell.00351.2018. Epub 2019 Jul 31. Am J Physiol Cell Physiol. 2019. PMID: 31365292 Free PMC article.
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