Lima WF - Search Results

1

Lipid nanoparticles improve activity of single-stranded siRNA and gapmer antisense oligonucleotides in animals.

Prakash TP, Lima WF, Murray HM, Elbashir S, Cantley W, Foster D, Jayaraman M, Chappell AE, Manoharan M, Swayze EE, Crooke ST. Prakash TP, et al. Among authors: lima wf. ACS Chem Biol. 2013 Jul 19;8(7):1402-6. doi: 10.1021/cb4001316. Epub 2013 May 2. ACS Chem Biol. 2013. PMID: 23614580

2

Single-stranded siRNAs activate RNAi in animals.

Lima WF, Prakash TP, Murray HM, Kinberger GA, Li W, Chappell AE, Li CS, Murray SF, Gaus H, Seth PP, Swayze EE, Crooke ST. Lima WF, et al. Cell. 2012 Aug 31;150(5):883-94. doi: 10.1016/j.cell.2012.08.014. Cell. 2012. PMID: 22939618 Free article.

3

Identification of metabolically stable 5'-phosphate analogs that support single-stranded siRNA activity.

Prakash TP, Lima WF, Murray HM, Li W, Kinberger GA, Chappell AE, Gaus H, Seth PP, Bhat B, Crooke ST, Swayze EE. Prakash TP, et al. Among authors: lima wf. Nucleic Acids Res. 2015 Mar 31;43(6):2993-3011. doi: 10.1093/nar/gkv162. Epub 2015 Mar 9. Nucleic Acids Res. 2015. PMID: 25753666 Free PMC article.

4

Synergistic effect of phosphorothioate, 5'-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA.

Prakash TP, Kinberger GA, Murray HM, Chappell A, Riney S, Graham MJ, Lima WF, Swayze EE, Seth PP. Prakash TP, et al. Among authors: lima wf. Bioorg Med Chem Lett. 2016 Jun 15;26(12):2817-2820. doi: 10.1016/j.bmcl.2016.04.063. Epub 2016 Apr 27. Bioorg Med Chem Lett. 2016. PMID: 27161280

5

Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs.

Wu H, Lima WF, Zhang H, Fan A, Sun H, Crooke ST. Wu H, et al. Among authors: lima wf. J Biol Chem. 2004 Apr 23;279(17):17181-9. doi: 10.1074/jbc.M311683200. Epub 2004 Feb 11. J Biol Chem. 2004. PMID: 14960586 Free article.

6

The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis.

Lima WF, Rose JB, Nichols JG, Wu H, Migawa MT, Wyrzykiewicz TK, Vasquez G, Swayze EE, Crooke ST. Lima WF, et al. Mol Pharmacol. 2007 Jan;71(1):73-82. doi: 10.1124/mol.106.025429. Epub 2006 Oct 6. Mol Pharmacol. 2007. PMID: 17028157

7

Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells.

Vickers TA, Lima WF, Nichols JG, Crooke ST. Vickers TA, et al. Among authors: lima wf. Nucleic Acids Res. 2007;35(19):6598-610. doi: 10.1093/nar/gkm663. Epub 2007 Sep 28. Nucleic Acids Res. 2007. PMID: 17905815 Free PMC article.

8

Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids.

Lima WF, Murray H, Nichols JG, Wu H, Sun H, Prakash TP, Berdeja AR, Gaus HJ, Crooke ST. Lima WF, et al. J Biol Chem. 2009 Jan 23;284(4):2535-48. doi: 10.1074/jbc.M803748200. Epub 2008 Nov 18. J Biol Chem. 2009. PMID: 19017633 Free article.

9

Binding and cleavage specificities of human Argonaute2.

Lima WF, Wu H, Nichols JG, Sun H, Murray HM, Crooke ST. Lima WF, et al. J Biol Chem. 2009 Sep 18;284(38):26017-28. doi: 10.1074/jbc.M109.010835. Epub 2009 Jul 22. J Biol Chem. 2009. PMID: 19625255 Free PMC article.

10

Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.

Vickers TA, Lima WF, Wu H, Nichols JG, Linsley PS, Crooke ST. Vickers TA, et al. Among authors: lima wf. Nucleic Acids Res. 2009 Nov;37(20):6927-41. doi: 10.1093/nar/gkp735. Epub 2009 Sep 18. Nucleic Acids Res. 2009. PMID: 19767612 Free PMC article.

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