Prakash TP - Search Results

1

Lipid nanoparticles improve activity of single-stranded siRNA and gapmer antisense oligonucleotides in animals.

Prakash TP, Lima WF, Murray HM, Elbashir S, Cantley W, Foster D, Jayaraman M, Chappell AE, Manoharan M, Swayze EE, Crooke ST. Prakash TP, et al. ACS Chem Biol. 2013 Jul 19;8(7):1402-6. doi: 10.1021/cb4001316. Epub 2013 May 2. ACS Chem Biol. 2013. PMID: 23614580

2

Single-stranded siRNAs activate RNAi in animals.

Lima WF, Prakash TP, Murray HM, Kinberger GA, Li W, Chappell AE, Li CS, Murray SF, Gaus H, Seth PP, Swayze EE, Crooke ST. Lima WF, et al. Among authors: prakash tp. Cell. 2012 Aug 31;150(5):883-94. doi: 10.1016/j.cell.2012.08.014. Cell. 2012. PMID: 22939618 Free article.

3

Synthesis and antisense properties of 2'-O-(2S-methoxypropyl)-RNA-modified gapmer antisense oligonucleotides.

Yu J, Pandey SK, Khatri H, Prakash TP, Swayze EE, Seth PP. Yu J, et al. Among authors: prakash tp. ChemMedChem. 2014 Sep;9(9):2040-4. doi: 10.1002/cmdc.201402099. Epub 2014 May 28. ChemMedChem. 2014. PMID: 24891270

4

Identification of metabolically stable 5'-phosphate analogs that support single-stranded siRNA activity.

Prakash TP, Lima WF, Murray HM, Li W, Kinberger GA, Chappell AE, Gaus H, Seth PP, Bhat B, Crooke ST, Swayze EE. Prakash TP, et al. Nucleic Acids Res. 2015 Mar 31;43(6):2993-3011. doi: 10.1093/nar/gkv162. Epub 2015 Mar 9. Nucleic Acids Res. 2015. PMID: 25753666 Free PMC article.

5

Synergistic effect of phosphorothioate, 5'-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA.

Prakash TP, Kinberger GA, Murray HM, Chappell A, Riney S, Graham MJ, Lima WF, Swayze EE, Seth PP. Prakash TP, et al. Bioorg Med Chem Lett. 2016 Jun 15;26(12):2817-2820. doi: 10.1016/j.bmcl.2016.04.063. Epub 2016 Apr 27. Bioorg Med Chem Lett. 2016. PMID: 27161280

6

Lipid Conjugates Enhance Endosomal Release of Antisense Oligonucleotides Into Cells.

Wang S, Allen N, Prakash TP, Liang XH, Crooke ST. Wang S, et al. Among authors: prakash tp. Nucleic Acid Ther. 2019 Oct;29(5):245-255. doi: 10.1089/nat.2019.0794. Epub 2019 Jun 3. Nucleic Acid Ther. 2019. PMID: 31158063

7

2'-modified-2-thiothymidine oligonucleotides.

Rajeev KG, Prakash TP, Manoharan M. Rajeev KG, et al. Among authors: prakash tp. Org Lett. 2003 Aug 21;5(17):3005-8. doi: 10.1021/ol0348607. Org Lett. 2003. PMID: 12916967

8

2'-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivo.

Prakash TP, Johnston JF, Graham MJ, Condon TP, Manoharan M. Prakash TP, et al. Nucleic Acids Res. 2004 Feb 3;32(2):828-33. doi: 10.1093/nar/gkh220. Print 2004. Nucleic Acids Res. 2004. PMID: 14762210 Free PMC article.

9

Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

Allerson CR, Sioufi N, Jarres R, Prakash TP, Naik N, Berdeja A, Wanders L, Griffey RH, Swayze EE, Bhat B. Allerson CR, et al. Among authors: prakash tp. J Med Chem. 2005 Feb 24;48(4):901-4. doi: 10.1021/jm049167j. J Med Chem. 2005. PMID: 15715458

10

Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications.

Dande P, Prakash TP, Sioufi N, Gaus H, Jarres R, Berdeja A, Swayze EE, Griffey RH, Bhat B. Dande P, et al. Among authors: prakash tp. J Med Chem. 2006 Mar 9;49(5):1624-34. doi: 10.1021/jm050822c. J Med Chem. 2006. PMID: 16509579

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