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Page 1
Pharmacologic profile of the Adnectin BMS-962476, a small protein biologic alternative to PCSK9 antibodies for low-density lipoprotein lowering.
Mitchell T, Chao G, Sitkoff D, Lo F, Monshizadegan H, Meyers D, Low S, Russo K, DiBella R, Denhez F, Gao M, Myers J, Duke G, Witmer M, Miao B, Ho SP, Khan J, Parker RA. Mitchell T, et al. Among authors: ho sp. J Pharmacol Exp Ther. 2014 Aug;350(2):412-24. doi: 10.1124/jpet.114.214221. Epub 2014 Jun 10. J Pharmacol Exp Ther. 2014. PMID: 24917546
Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.
Khetarpal SA, Schjoldager KT, Christoffersen C, Raghavan A, Edmondson AC, Reutter HM, Ahmed B, Ouazzani R, Peloso GM, Vitali C, Zhao W, Somasundara AV, Millar JS, Park Y, Fernando G, Livanov V, Choi S, Noé E, Patel P, Ho SP; Myocardial Infarction Exome Sequencing Study; Kirchgessner TG, Wandall HH, Hansen L, Bennett EP, Vakhrushev SY, Saleheen D, Kathiresan S, Brown CD, Abou Jamra R, LeGuern E, Clausen H, Rader DJ. Khetarpal SA, et al. Among authors: ho sp. Cell Metab. 2016 Aug 9;24(2):234-45. doi: 10.1016/j.cmet.2016.07.012. Cell Metab. 2016. PMID: 27508872 Free PMC article.
Double-Stranded RNA-Based Method for Diagnosing Severe Fever with Thrombocytopenia.
Park JW, Jeon J, Kim Y, Jeon MH. Park JW, et al. J Clin Med. 2024 Dec 28;14(1):105. doi: 10.3390/jcm14010105. J Clin Med. 2024. PMID: 39797188 Free PMC article.
Methods: Blood samples from SFTS patients were collected, dsRNA was purified, and total dsRNA expression was quantitatively analyzed using a spiropyran-based method. Comparative analysis was performed using blood samples from healthy individuals and scrub typhus patients w …
Methods: Blood samples from SFTS patients were collected, dsRNA was purified, and total dsRNA expression was quantitatively analyzed using a …
Upconverting/magnetic Janus-like nanoparticles integrated into spiropyran micelle-like nanocarriers for NIR light- and pH- responsive drug delivery, photothermal therapy and biomedical imaging.
Espinola-Portilla F, d'Orlyé F, Molina González JA, Trapiella-Alfonso L, Gutiérrez-Granados S, Varenne A, Ramírez-García G. Espinola-Portilla F, et al. Colloids Surf B Biointerfaces. 2025 Jan 7;249:114501. doi: 10.1016/j.colsurfb.2025.114501. Online ahead of print. Colloids Surf B Biointerfaces. 2025. PMID: 39793211
JNPs were encapsulated together with doxorubicin (Dox) into micelle-like aggregates formed with the stimuli-responsive Poly(NIPAM-co-Spiropyran) copolymer, which responds to UV light, temperature changes, and pH variations, so as to form the JNP-Dox@Mic nanocarrier. Based …
JNPs were encapsulated together with doxorubicin (Dox) into micelle-like aggregates formed with the stimuli-responsive Poly(NIPAM-co-Spir …
Light-/pH-Regulated Spiropyran Smart-Responsive Hydrophilic Separation Platform for the Identification of Serum Glycopeptides from Hepatocellular Carcinoma Patients.
Zhao Y, Li H, Zheng H, Jia Q. Zhao Y, et al. Anal Chem. 2025 Jan 7. doi: 10.1021/acs.analchem.4c04025. Online ahead of print. Anal Chem. 2025. PMID: 39772462
In this work, for the first time, we developed a smart enrichment strategy (MNPs-l-DOPA/PEI-SP) based on the change in hydrophilic properties of spiropyran under the regulation of light and pH to realize the controllable enrichment and release of intact glycopeptides. ...
In this work, for the first time, we developed a smart enrichment strategy (MNPs-l-DOPA/PEI-SP) based on the change in hydrophilic propertie …
Phase-Separated Spiropyran Coacervates as Dual-Wavelength-Switchable Reactive Oxygen Generators.
Xia J, Kong H, Xie X, Bao Y, Zhang F, Bian L, Cheng K, Zhao YD. Xia J, et al. Angew Chem Int Ed Engl. 2025 Jan 2:e202419538. doi: 10.1002/anie.202419538. Online ahead of print. Angew Chem Int Ed Engl. 2025. PMID: 39746885
Here, we report photochemical reactions of spiropyran (SP)-based coacervates with two wavelengths of light, in vitro, in the cell, and in animals, generating reactive oxygen species (ROS) for photo-controlled cell killing. ...Light-induced ROS generation leads to cytotoxic …
Here, we report photochemical reactions of spiropyran (SP)-based coacervates with two wavelengths of light, in vitro, in the cell, an …
Dynamic Covalent Spiropyran Exchange for Rapid Structural Diversification.
Drichel A, Garmshausen Y, Hecht S. Drichel A, et al. Angew Chem Int Ed Engl. 2025 Jan 2:e202419531. doi: 10.1002/anie.202419531. Online ahead of print. Angew Chem Int Ed Engl. 2025. PMID: 39745144
The rate and position of the exchange equilibrium strongly depend on the reaction conditions as well as the substitution pattern on the methylene indoline fragments. Importantly, spiropyran cross exchange is catalyzed by indolinium salts and provides the opportunity for ra …
The rate and position of the exchange equilibrium strongly depend on the reaction conditions as well as the substitution pattern on the meth …
Systematic review: Mechanisms of photoactive nanocarriers for imaging and therapy including controlled drug delivery.
Zhang Y, Qiu Y, Karimi AB, Smith BR. Zhang Y, et al. Eur J Nucl Med Mol Imaging. 2024 Dec 26. doi: 10.1007/s00259-024-07014-z. Online ahead of print. Eur J Nucl Med Mol Imaging. 2024. PMID: 39722062 Review.
We found that six mechanisms (photocleavage, photoisomerization, photopolymerization, photosensitization, photothermal phenomena, and photorearrangement) have primarily been used for light-triggered drug release and categorized our review accordingly. Azobenzene/spiropyran …
We found that six mechanisms (photocleavage, photoisomerization, photopolymerization, photosensitization, photothermal phenomena, and photor …
Preparation of light-responsive polyacrylamide/carboxymethyl chitosan composite aerogel and its adsorption performance for Li.
Wang J, Li R, Wang J, Gao Y, Wang M, Wang H. Wang J, et al. Int J Biol Macromol. 2024 Dec 18;291:138980. doi: 10.1016/j.ijbiomac.2024.138980. Online ahead of print. Int J Biol Macromol. 2024. PMID: 39706450
As an essential material for manufacturing lithium batteries, the demand of lithium is increasing, which means novel extracting method from various lithium-containing solutions is necessary. Spiropyran molecules undergo a photoisomerization reaction under light, transition …
As an essential material for manufacturing lithium batteries, the demand of lithium is increasing, which means novel extracting method from …
1,113 results